Pressurized Intraperitoneal Aerosol Chemotherapy-Related Clinical Trials in the Treatment of Peritoneal Metastases.

Ukegjini, Kristjan; Putora, Paul Martin; Guidi, Marisa; Süveg, Krisztian; Cihoric, Nikola; Widmann, Bernhard; Steffen, Thomas (2021). Pressurized Intraperitoneal Aerosol Chemotherapy-Related Clinical Trials in the Treatment of Peritoneal Metastases. Oncology - international journal of cancer research and treatment, 99(9), pp. 601-610. Karger 10.1159/000516959

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INTRODUCTION

Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a treatment option for patients with peritoneal metastases. We evaluated the current status of ongoing prospective clinical trials investigating PIPAC to provide an overview and predict trends in this field.

METHODS

All 367,494 records of clinical trials registered at ClinicalTrials.gov were searched for trials dealing with PIPAC. Active or unpublished trials were further analyzed.

RESULTS

In total, 22 clinical trials were identified and selected for further analyses. Most trials had a single-arm design and were phase I or II. No phase III trials were registered. Academic centers were recorded as primary sponsors in the majority of trials (63.6%). Every year, between 2 and 5 new trials were initiated. In 17 trials (81.8%), PIPAC was used in a palliative setting only, 2 trials performed PIPAC in a neoadjuvant setting, and 2 trials performed PIPAC in an adjuvant setting. Six different drugs (doxorubicin, cisplatin, oxaliplatin, nab-paclitaxel, 5-fluorouracil, and docetaxel) were used in these clinical trials. Most trials investigated the efficacy (n = 15) or safety (n = 7) of PIPAC therapies.

CONCLUSIONS

The results of ongoing clinical trials will bring specific information on indications for PIPAC as well as the impact of PIPAC on quality of life and overall survival.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Putora, Paul Martin and Cihoric, Nikola

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0030-2414

Publisher:

Karger

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

20 Jul 2021 11:39

Last Modified:

28 Aug 2021 01:33

Publisher DOI:

10.1159/000516959

PubMed ID:

34265774

Uncontrolled Keywords:

ClinicalTrials.gov Ongoing prospective clinical trials Peritoneal malignancy therapy Peritoneal metastases Pressurized intraperitoneal aerosol chemotherapy

URI:

https://boris.unibe.ch/id/eprint/157619

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