Kyathanahally, Sreenath P; Azzarito, Michela; Rosner, Jan; Calhoun, Vince D; Blaiotta, Claudia; Ashburner, John; Weiskopf, Nikolaus; Wiech, Katja; Friston, Karl; Ziegler, Gabriel; Freund, Patrick (2021). Microstructural plasticity in nociceptive pathways after spinal cord injury. (In Press). Journal of neurology, neurosurgery, and psychiatry, 92(8), pp. 863-871. BMJ Publishing Group 10.1136/jnnp-2020-325580
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OBJECTIVE
To track the interplay between (micro-) structural changes along the trajectories of nociceptive pathways and its relation to the presence and intensity of neuropathic pain (NP) after spinal cord injury (SCI).
METHODS
A quantitative neuroimaging approach employing a multiparametric mapping protocol was used, providing indirect measures of myelination (via contrasts such as magnetisation transfer (MT) saturation, longitudinal relaxation (R1)) and iron content (via effective transverse relaxation rate (R2*)) was used to track microstructural changes within nociceptive pathways. In order to characterise concurrent changes along the entire neuroaxis, a combined brain and spinal cord template embedded in the statistical parametric mapping framework was used. Multivariate source-based morphometry was performed to identify naturally grouped patterns of structural variation between individuals with and without NP after SCI.
RESULTS
In individuals with NP, lower R1 and MT values are evident in the primary motor cortex and dorsolateral prefrontal cortex, while increases in R2* are evident in the cervical cord, periaqueductal grey (PAG), thalamus and anterior cingulate cortex when compared with pain-free individuals. Lower R1 values in the PAG and greater R2* values in the cervical cord are associated with NP intensity.
CONCLUSIONS
The degree of microstructural changes across ascending and descending nociceptive pathways is critically implicated in the maintenance of NP. Tracking maladaptive plasticity unravels the intimate relationships between neurodegenerative and compensatory processes in NP states and may facilitate patient monitoring during therapeutic trials related to pain and neuroregeneration.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Rosner, Jan |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1468-330X |
Publisher: |
BMJ Publishing Group |
Language: |
English |
Submitter: |
Chantal Kottler |
Date Deposited: |
26 Jul 2021 13:41 |
Last Modified: |
05 Dec 2022 15:52 |
Publisher DOI: |
10.1136/jnnp-2020-325580 |
PubMed ID: |
34039630 |
BORIS DOI: |
10.48350/157651 |
URI: |
https://boris.unibe.ch/id/eprint/157651 |
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