Marjańska, Małgorzata; Deelchand, Dinesh K; Kreis, Roland (2022). Results and interpretation of a fitting challenge for MR spectroscopy set up by the MRS study group of ISMRM. Magnetic resonance in medicine, 87(1), pp. 11-32. Wiley-Liss 10.1002/mrm.28942
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PURPOSE
Fitting of MRS data plays an important role in the quantification of metabolite concentrations. Many different spectral fitting packages are used by the MRS community. A fitting challenge was set up to allow comparison of fitting methods on the basis of performance and robustness.
METHODS
Synthetic data were generated for 28 datasets. Short-echo time PRESS spectra were simulated using ideal pulses for the common metabolites at mostly near-normal brain concentrations. Macromolecular contributions were also included. Modulations of signal-to-noise ratio (SNR); lineshape type and width; concentrations of γ-aminobutyric acid, glutathione, and macromolecules; and inclusion of artifacts and lipid signals to mimic tumor spectra were included as challenges to be coped with.
RESULTS
Twenty-six submissions were evaluated. Visually, most fit packages performed well with mostly noise-like residuals. However, striking differences in fit performance were found with bias problems also evident for well-known packages. In addition, often error bounds were not appropriately estimated and deduced confidence limits misleading. Soft constraints as used in LCModel were found to substantially influence the fitting results and their dependence on SNR.
CONCLUSIONS
Substantial differences were found for accuracy and precision of fit results obtained by the multiple fit packages.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM) 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) 04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology |
UniBE Contributor: |
Kreis, Roland |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0740-3194 |
Publisher: |
Wiley-Liss |
Language: |
English |
Submitter: |
Maria de Fatima Henriques Bernardo |
Date Deposited: |
16 Aug 2021 16:35 |
Last Modified: |
24 Mar 2023 14:23 |
Publisher DOI: |
10.1002/mrm.28942 |
PubMed ID: |
34337767 |
Uncontrolled Keywords: |
1H MRS analysis brain fitting quantification spectrum |
BORIS DOI: |
10.48350/157895 |
URI: |
https://boris.unibe.ch/id/eprint/157895 |
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