Sundararaman, Sai Sahana; Döring, Yvonne; van der Vorst, Emiel P C (2021). PCSK9: A Multi-Faceted Protein That Is Involved in Cardiovascular Biology. Biomedicines, 9(7) MDPI 10.3390/biomedicines9070793
|
Text
SundararamanS_PCSK3Multi-FacetedProtInvolvedInCardiovascBiology_biomedicines_2021.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (3MB) | Preview |
Pro-protein convertase subtilisin/kexin type 9 (PCSK9) is secreted mostly by hepatocytes and to a lesser extent by the intestine, pancreas, kidney, adipose tissue, and vascular cells. PCSK9 has been known to interact with the low-density lipoprotein receptor (LDLR) and chaperones the receptor to its degradation. In this manner, targeting PCSK9 is a novel attractive approach to reduce hyperlipidaemia and the risk for cardiovascular diseases. Recently, it has been recognised that the effects of PCSK9 in relation to cardiovascular complications are not only LDLR related, but that various LDLR-independent pathways and processes are also influenced. In this review, the various LDLR dependent and especially independent effects of PCSK9 on the cardiovascular system are discussed, followed by an overview of related PCSK9-polymorphisms and currently available and future therapeutic approaches to manipulate PCSK9 expression.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology |
UniBE Contributor: |
Döring, Yvonne |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2227-9059 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Rebecca Scheidegger |
Date Deposited: |
26 Aug 2021 10:54 |
Last Modified: |
18 Feb 2024 19:23 |
Publisher DOI: |
10.3390/biomedicines9070793 |
PubMed ID: |
34356856 |
Uncontrolled Keywords: |
PCSK9 cardiovascular disorders cholesterol low density lipoprotein receptor monoclonal antibodies polymorphisms |
BORIS DOI: |
10.48350/157973 |
URI: |
https://boris.unibe.ch/id/eprint/157973 |
Actions (login required)
 |
Edit item |