Association between symptoms and quality of life in patients with schizophrenia: a pooled analysis of changes over time

Priebe, Stefan; McCabe, Rosemarie; Junghan, Ulrich; Kallert, Thomas; Ruggeri, Mirella; Slade, Mike; Reininghaus, Ulrich (2011). Association between symptoms and quality of life in patients with schizophrenia: a pooled analysis of changes over time. Schizophrenia Research, 133(1-3), pp. 17-21. Elsevier 10.1016/j.schres.2011.09.021

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Quality of life is an important outcome in the treatment of patients with schizophrenia. It has been suggested that patients' quality of life ratings (referred to as subjective quality of life, SQOL) might be too heavily influenced by symptomatology to be a valid independent outcome criterion. There has been only limited evidence on the association of symptom change and changes in SQOL over time. This study aimed to examine the association between changes in symptoms and in SQOL among patients with schizophrenia. A pooled data set was obtained from eight longitudinal studies that had used the Brief Psychiatric Rating Scale (BPRS) for measuring psychiatric symptoms and either the Lancashire Quality of Life Profile or the Manchester Short Assessment of Quality of Life for assessing SQOL. The sample comprised 886 patients with schizophrenia. After controlling for heterogeneity of findings across studies using linear mixed models, a reduction in psychiatric symptoms was associated with improvements in SQOL scores. In univariate analyses, changes in all BPRS subscales were associated with changes in SQOL scores. In a multivariate model, only associations between changes in the BPRS depression/anxiety and hostility subscales and changes in SQOL remained significant, with 5% and 0.5% of the variance in SQOL changes being attributable to changes in depression/anxiety and hostility respectively. All BPRS subscales together explained 8.5% of variance. The findings indicate that SQOL changes are influenced by symptom change, in particular in depression/anxiety. The level of influence is limited and may not compromise using SQOL as an independent outcome measure.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychotherapy

UniBE Contributor:

Junghan, Ulrich M.








Factscience Import

Date Deposited:

04 Oct 2013 14:39

Last Modified:

06 Mar 2014 19:41

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URI: (FactScience: 223263)

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