Sirolimus and everolimus reduce albumin endocytosis in proximal tubule cells via an angiotensin II-dependent pathway

Oroszlán, Melinda; Bieri, Michael; Ligeti, Nathalie; Farkas, Anikó; Meier, Bernhard; Marti, Hans-Peter; Mohacsi, Paul (2010). Sirolimus and everolimus reduce albumin endocytosis in proximal tubule cells via an angiotensin II-dependent pathway. Transplant immunology, 23(3), pp. 125-32. Amsterdam: Elsevier 10.1016/j.trim.2010.05.003

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The proliferation signal inhibitors (PSIs) sirolimus (SRL) and everolimus (ERL) often induce proteinuria due to glomerular but also tubular dysfunction in transplant patients. The beneficial effect of angiotensin converting enzyme inhibitors (ACE-I) and angiotensin II (Ang II) type 1 receptor blockers (ARB) has been reported.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Oroszlan, Melinda; Meier, Bernhard; Marti, Hans-Peter and Mohacsi, Paul

ISSN:

0966-3274

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:10

Last Modified:

04 May 2014 23:05

Publisher DOI:

10.1016/j.trim.2010.05.003

PubMed ID:

20470887

Web of Science ID:

000280210100006

URI:

https://boris.unibe.ch/id/eprint/1582 (FactScience: 203359)

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