Neutrophil extracellular traps in cancer.

Cristinziano, Leonardo; Modestino, Luca; Antonelli, Alessandro; Marone, Gianni; Simon, Hans-Uwe; Varricchi, Gilda; Galdiero, Maria Rosaria (2021). Neutrophil extracellular traps in cancer. (In Press). Seminars in cancer biology Elsevier 10.1016/j.semcancer.2021.07.011

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Beyond their well-known functions in the acute phases of the immune response, neutrophils play important roles in the various phases of tumor initiation and progression, through the release of their stored or newly synthesized mediators. In addition to reactive oxygen species, cytokines, chemokines, granule proteins and lipid mediators, neutrophil extracellular traps (NETs) can also be released upon neutrophil activation. NET formation can be achieved through a cell-death process or in association with the release of mitochondrial DNA from viable neutrophils. NETs are described as extracellular fibers of DNA and decorating proteins responsible for trapping and killing extracellular pathogens, playing a protective role in the antimicrobial defense. There is increasing evidence, however, that NETs play multiple roles in the scenario of cancer-related inflammation. For instance, NETs directly or indirectly promote tumor growth and progression, fostering tumor spread at distant sites and shielding cancer cells thus preventing the effects of cytotoxic lymphocytes. NETs can also promote tumor angiogenesis and cancer-associated thrombosis. On the other hand, there is some evidence that NETs may play anti-inflammatory and anti-tumorigenic roles. In this review, we focus on the main mechanisms underlying the emerging effects of NETs in cancer initiation and progression.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1096-3650

Publisher:

Elsevier

Language:

English

Submitter:

Celine Joray

Date Deposited:

08 Sep 2021 08:25

Last Modified:

08 Sep 2021 08:25

Publisher DOI:

10.1016/j.semcancer.2021.07.011

PubMed ID:

34280576

Uncontrolled Keywords:

Angiogenesis Cancer Inflammation Neutrophil Neutrophil extracellular trap

BORIS DOI:

10.48350/158317

URI:

https://boris.unibe.ch/id/eprint/158317

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