Increased Fetal Cardiovascular Disease Risk: Potential Synergy Between Gestational Diabetes Mellitus and Maternal Hypercholesterolemia.

Espinoza, Cristian; Fuenzalida, Barbara; Leiva, Andrea (2021). Increased Fetal Cardiovascular Disease Risk: Potential Synergy Between Gestational Diabetes Mellitus and Maternal Hypercholesterolemia. Current vascular pharmacology, 19(6), pp. 601-623. Bentham Science 10.2174/1570161119666210423085407

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Cardiovascular diseases (CVD) remain a major cause of death worldwide. Evidence suggests that the risk for CVD can increase at fetal stages due to maternal metabolic diseases such as gestational diabetes mellitus (GDM) and maternal supraphysiological hypercholesterolemia (MSPH). GDM is a hyperglycemic, inflammatory and insulin-resistant state that increases plasma levels of free fatty acids and triglycerides, impairs endothelial vascular tone regulation and, due to increased nutrient transport, exposes the fetus to the altered metabolic conditions of the mother. MSPH involves increased levels of cholesterol (mainly as low-density lipoprotein cholesterol) which also causes endothelial dysfunction and alters nutrient transport to the fetus. Despite that an association has already been established between MSPH and increased CVD risk, little is known about the cellular processes underlying this relationship. Our knowledge is further obscured when simultaneous presentation of MSPH and GDM takes place. In this context, GDM and MSPH may substantially increase fetal CVD risk due to synergistic impairment of placental nutrient transport and endothelial dysfunction. More studies on the separate and/or cumulative role of both processes are warranted to suggest specific treatment options.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Fuenzalida Saavedra, Barbara Marlene

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1875-6212

Publisher:

Bentham Science

Language:

English

Submitter:

Barbara Franziska Järmann-Bangerter

Date Deposited:

16 Jun 2022 15:57

Last Modified:

05 Dec 2022 15:52

Publisher DOI:

10.2174/1570161119666210423085407

PubMed ID:

33902412

Uncontrolled Keywords:

Dyslipidemia cardiovascular disease. endothelium gestational diabetes pregnancy

BORIS DOI:

10.48350/158331

URI:

https://boris.unibe.ch/id/eprint/158331

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