Detection of Chlamydia and complement factors in neovascular membranes of patients with age-related macular degeneration

Wolf-Schnurrbusch, Ute E. K.; Hess, Roberto; Jordi, Florian; Stuck, Anna; Sarra, Gian-Marco; Wolf, Sebastian; Enzmann, Volker (2013). Detection of Chlamydia and complement factors in neovascular membranes of patients with age-related macular degeneration. Ocular immunology and inflammation, 21(1), pp. 36-43. New York, N.Y.: Informa Healthcare 10.3109/09273948.2012.726393

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PURPOSE To investigate whether Chlamydia pneumoniae and complement factors were present in surgically removed choroidal neovascular membranes (CNV) of patients with age-related macular degeneration (AMD). METHODS Paraffin sections of 26 CNV were stained for C. pneumoniae or the complement factors H (CFH) and C5, whereas macrophages were identified by positive CD68 staining. Clinical characteristics have been correlated to the immunohistochemical findings. RESULTS C. pneumoniae was found in 68% of the investigated membranes, and 88% of these membranes were also positive for CD68. Staining for CFH and C5 gave a positive reaction in 68 and 41% of the membranes, respectively. Patients with C5-positive membranes had significantly larger CNV mean area and were younger than patients with CFH-positive membranes at the operation time point. CONCLUSIONS Correlations between clinical symptoms and complement factor C5 could be shown. The results strengthen the hypothesis of an involvement of the complement system in AMD.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology
04 Faculty of Medicine > Service Sector > Institute of Pathology > Autopsy

UniBE Contributor:

Wolf-Schnurrbusch, Ute; Hess, Roberto; Stuck, Anna; Sarra, Gian-Marco; Wolf, Sebastian and Enzmann, Volker

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0927-3948

Publisher:

Informa Healthcare

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:39

Last Modified:

03 Jul 2014 10:26

Publisher DOI:

10.3109/09273948.2012.726393

PubMed ID:

23590149

URI:

https://boris.unibe.ch/id/eprint/15837 (FactScience: 223313)

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