Abdominal pain in patients with inflammatory bowel disease: association with single-nucleotide polymorphisms prevalent in irritable bowel syndrome and clinical management.

Ledergerber, Martina; Lang, Brian M; Heinrich, Henriette; Biedermann, Luc; Begré, Stefan; Zeitz, Jonas; Krupka, Niklas; Rickenbacher, Andreas; Turina, Matthias; Greuter, Thomas; Schreiner, Philipp; Roth, René; Siebenhüner, Alexander; Vavricka, Stephan R; Rogler, Gerhard; Beerenwinkel, Niko; Misselwitz, Benjamin (2021). Abdominal pain in patients with inflammatory bowel disease: association with single-nucleotide polymorphisms prevalent in irritable bowel syndrome and clinical management. BMC gastroenterology, 21(1), p. 53. BioMed Central 10.1186/s12876-021-01622-x

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BACKGROUND

Abdominal pain is a frequent symptom in patients with inflammatory bowel disease (IBD) including Crohn's disease (CD) and ulcerative colitis (UC). Pain can result from ongoing inflammation or functional disorders imitating irritable bowel syndrome (IBS). Several single-nucleotide polymorphisms (SNPs) have been associated with IBS. However, the impact of IBS genetics on the clinical course of IBD, especially pain levels of patients remains unclear.

METHODS

Data of 857 UC and 1206 CD patients from the Swiss IBD Cohort Study were analysed. We tested the association of the maximum of the abdominal pain item of disease activity indices in UC and CD over the study period with 16 IBS-associated SNPs, using multivariate ANOVA models.

RESULTS

In UC patients, the SNPs rs1042713 (located on the ADRB2 gene) and rs4663866 (close to the HES6 gene) were associated with higher abdominal pain levels (P = 0.044; P = 0.037, respectively). Abdominal pain was not associated with any markers of patient management in a model adjusted for confounders. In CD patients, higher levels of abdominal pain correlated with the number of physician contacts (P < 10-15), examinations (P < 10-12), medical therapies (P = 0.023) and weeks of hospitalisation (P = 0.0013) in a multivariate model.

CONCLUSIONS

We detected an association between maximal abdominal pain in UC patients and two IBS-associated SNPs. Abdominal pain levels had a pronounced impact on diagnostic and therapeutic procedures in CD but not in UC patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie

UniBE Contributor:

Begré, Stefan; Krupka, Niklas and Misselwitz, Benjamin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1471-230X

Publisher:

BioMed Central

Language:

English

Submitter:

Rahel Fuhrer

Date Deposited:

15 Sep 2021 11:21

Last Modified:

15 Sep 2021 11:22

Publisher DOI:

10.1186/s12876-021-01622-x

PubMed ID:

33546600

Uncontrolled Keywords:

Abdominal pain Crohn’s disease Inflammatory bowel disease Irritable bowel syndrome Single-nucleotide polymorphisms Ulcerative colitis

BORIS DOI:

10.48350/158979

URI:

https://boris.unibe.ch/id/eprint/158979

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