Type D personality is associated with depressive symptoms and clinical activity in inflammatory bowel disease.

Jordi, Sebastian Bruno Ulrich; Botte, Federica; Lang, Brian Matthew; Greuter, Thomas; Krupka, Niklas; Auschra, Bianca; Schreiner, Philipp; Sulz, Michael Christian; Biedermann, Luc; von Känel, Roland; Rogler, Gerhard; Begré, Stefan; Misselwitz, Benjamin (2021). Type D personality is associated with depressive symptoms and clinical activity in inflammatory bowel disease. Alimentary pharmacology & therapeutics, 54(1), pp. 53-67. Wiley-Blackwell 10.1111/apt.16365

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BACKGROUND

Inflammatory bowel disease (IBD) can be exacerbated by stress and depression. Type D personality, characterised by high negative affectivity and social inhibition, represents a vulnerability towards stressors and is associated with adverse outcomes in coronary heart disease.

AIMS

To assess the prevalence of Type D personality in IBD patients and investigate potential associations with disease course.

METHODS

We tested for associations between Type D (Type D Scale-14), depressive symptoms (Hospital Anxiety and Depression Scale's depression subscore ≥11) and recurrent IBD amongst Swiss IBD cohort patients. We built regression models for cross-sectional and Cox proportional hazards models for time-to-event analyses. IBD disease course was assessed by the future occurrence of active disease (Crohn's Disease Activity Index ≥150/Modified Truelove & Witts activity index ≥10) and several IBD-relevant endpoints.

RESULTS

Amongst 2275 patients (1005 ulcerative colitis, 1270 Crohn's disease), 672 (29.5%) had Type D. Type D was a significant risk factor for future active disease (adjusted hazard ratio, aHR: 1.60, corrected P value, q = 0.007) and predicted the future presence of depressive symptoms (aHR: 3.30, P < 0.001). The combination of Type D and depressive symptoms further increased the risk for active disease (aHR: 3.98, q < 0.001). However, Type D associated depressive symptoms seemed to be the main contributor to this effect as Type D's predictive power decreased considerably in models corrected for depressive symptoms (aHR: 1.32, CI: 0.97-1.79, q = 0.292).

CONCLUSIONS

Type D personality's prevalence amongst IBD patients was comparable with its prevalence in the general population. Type D was strongly associated with depressive symptoms and showed modest independent associations with IBD prognosis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)

UniBE Contributor:

Botte, Federica Maria Alfonsina; Krupka, Niklas; Begré, Stefan and Misselwitz, Benjamin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0269-2813

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Rahel Fuhrer

Date Deposited:

20 Sep 2021 12:56

Last Modified:

20 Sep 2021 12:56

Publisher DOI:

10.1111/apt.16365

PubMed ID:

33975385

BORIS DOI:

10.48350/159101

URI:

https://boris.unibe.ch/id/eprint/159101

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