Schmid, Adrian A.; Morelli, John N.; Hungerbühler, Martin N.; Boehm, Ingrid B. (2021). Cross-reactivity among iodinated contrast agents: should we be concerned? Quantitative imaging in medicine and surgery, 11(9), pp. 4028-4041. AME Publishing Company 10.21037/qims-20-1325
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Background
Although several papers deal with "cross-reactivity" in patients with iodinated contrast medium (ICM) hypersensitivity reactions (HSRs), there is no in-depth knowledge of this phenomenon. To define ICM-groups as potential reaction partners and to identify any potential clinical relevance in patients with ICM-HSRs.
Methods
The literature database PubMed was searched for eligible papers dealing with ICM-allergy and "cross-reactivity". The data presented by the papers was analyzed and individual patient data was extracted for re-evaluation based on a definition for both 'polyvalent reactivity' and 'cross-reactivity' as well as for chemical structure-dependent ICM-groups.
Results
Twenty-five original papers (with n=340 extracted patients) formed the study population. Incidences of polyvalent reactivity were non-significantly higher than incidences of cross-reactivity (both range from 0% to 100%). Crossover evaluation in reaction pairings (culprit ICM A with ICM B versus culprit ICM B with ICM A) showed concordance of only 30%. Data support rather non-cross-reactivity (individual reaction pattern) than cross-reactivity constellations.
Conclusions
The obtained results favour an individual reaction pattern, rather than a reactivity driven by chemical structures and so-called cross-reactivity.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology |
UniBE Contributor: |
Böhm, Ingrid |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2223-4292 |
Publisher: |
AME Publishing Company |
Language: |
English |
Submitter: |
Maria de Fatima Henriques Bernardo |
Date Deposited: |
24 Sep 2021 14:48 |
Last Modified: |
05 Dec 2022 15:53 |
Publisher DOI: |
10.21037/qims-20-1325 |
PubMed ID: |
34476187 |
Uncontrolled Keywords: |
Cross-reactivity drug provocation test (DPT) hypersensitivity reaction (HSR) immediate reaction (IR) iodinated contrast medium (ICM) non-immediate reaction (NIR) polyvalent reactions risk stratification |
BORIS DOI: |
10.48350/159186 |
URI: |
https://boris.unibe.ch/id/eprint/159186 |
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