Function of Connexin-43 in Macrophages.

Rodjakovic, Daniel; Salm, Lilian; Beldi, Guido (2021). Function of Connexin-43 in Macrophages. International journal of molecular sciences, 22(3) Molecular Diversity Preservation International MDPI 10.3390/ijms22031412

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Recent studies have helped to increase the understanding of the function of Connexin-43 (Cx43) in macrophages (Mφ). The various roles of Cx43 in Mφs range from migration, antigen-presentation and some forms of intercellular communication to more delicate processes, such as electrochemical support in the propagation of the heartbeat, immunomodulatory regulation in the lungs and in macrophage-differentiation. Its relevance in pathophysiology becomes evident in inflammatory bowel disease (IBD), tumours and HIV, in which aberrant functioning of Cx43 has been described. However, the involvement of Cx43 in other Mφ functions, such as phagocytosis and polarisation, and its involvement in other types of local and systemic inflammation, are still unclear and need further research.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Viszeralchirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Viszeralchirurgie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery

UniBE Contributor:

Rodjakovic, Daniel; Salm, Lilian and Beldi, Guido

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1661-6596

Publisher:

Molecular Diversity Preservation International MDPI

Language:

English

Submitter:

Rahel Fuhrer

Date Deposited:

22 Sep 2021 15:37

Last Modified:

22 Sep 2021 15:37

Publisher DOI:

10.3390/ijms22031412

PubMed ID:

33573367

Uncontrolled Keywords:

Cx43 connexin connexin-43 gap junction gja1 hemichannel macrophage mechanisms pathophysiology physiology

BORIS DOI:

10.48350/159218

URI:

https://boris.unibe.ch/id/eprint/159218

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