Oral function in amyotrophic lateral sclerosis patients: A matched case-control study.

Schimmel, Martin; Leuchter, Igor; Héritier Barras, Anne-Chantal; Leles, Claudio R; Abou-Ayash, Samir; Viatte, Valérie; Esteve, Françoise; Janssens, Jean-Paul; Mueller, Frauke; Genton, Laurence (2021). Oral function in amyotrophic lateral sclerosis patients: A matched case-control study. Clinical nutrition, 40(8), pp. 4904-4911. Elsevier 10.1016/j.clnu.2021.06.022

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BACKGROUND & AIMS

Patients with amyotrophic lateral sclerosis (ALS) develop swallowing difficulties with the progression of the disease. The present study aimed at comparing oral function and body composition between ALS patients and healthy controls, and at evaluating which parameters are the most discriminant between both groups.

METHODS

We included ALS patients at the start of their multidisciplinary follow-up at the Geneva University Hospitals and healthy age-, gender-, and dental status-matched adults. We assessed the severity of the disease through the ALS Functional Rating Scale and the swallowing difficulties through the EAT-10 score. We performed an intraoral examination of the dental status, and measured chewing performance, bite, lip and tongue force, saliva weight, and body composition. Group comparisons were performed with t-tests or Mann-Whitney tests as appropriate. Linear discriminant analysis was used to determine the most discriminant parameters between groups.

RESULTS

Twenty-six ALS patients (bulbar onset: n = 7, median (IQR) ALS Functional Rating Scale: 37 (11)) were included. The ALS patients had a significantly lower chewing performance (p < 0.001), lip force (p < 0.001), tongue force (p = 0.002), saliva weight (p < 0.004) and fat-free mass index (p < 0.001) as compared to the healthy individuals, and a higher EAT-10 score (p < 0.001). In ALS patients, a low chewing performance was correlated with a low bite (r = -0.45, p < 0.05)) and tongue force (r = -0.59, p < 0.05). The most discriminant parameters between both groups, by order of importance, were chewing performance, fat-free mass index and saliva weight and allowed the calculation of a discriminant function.

CONCLUSION

Compared to healthy controls, ALS patients have significant alterations of oral function and body composition. The most discriminant parameters between both groups were chewing performance, fat-free mass index and saliva volume. It remains to be demonstrated whether oral parameters predict outcome. CLINICAL TRIAL REGISTRY: clinicaltrials.gov, identifier: NCT01772888.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Reconstructive Dentistry and Gerodontology

UniBE Contributor:

Schimmel, Martin and Abou-Ayash, Samir

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0261-5614

Publisher:

Elsevier

Language:

English

Submitter:

Lena Augé

Date Deposited:

29 Sep 2021 08:04

Last Modified:

29 Sep 2021 08:04

Publisher DOI:

10.1016/j.clnu.2021.06.022

PubMed ID:

34358835

Uncontrolled Keywords:

Chewing efficiency Fat-free mass Lip force Oral function Saliva Tongue force

BORIS DOI:

10.48350/159259

URI:

https://boris.unibe.ch/id/eprint/159259

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