Diagnosis and Management of Pain in Parkinson's Disease: A New Approach.

Mylius, Veit; Möller, Jens Carsten; Bohlhalter, Stephan; Ciampi de Andrade, Daniel; Perez Lloret, Santiago (2021). Diagnosis and Management of Pain in Parkinson's Disease: A New Approach. Drugs & aging, 38(7), pp. 559-577. Springer 10.1007/s40266-021-00867-1

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Pain is a frequent and disabling non-motor feature of Parkinson's disease (PD). The recently proposed PD Pain Classification System (PD-PCS) allows for an association of pain with PD to be determined before being allocated to the main pain mechanism (i.e. nociceptive, neuropathic, and nociplastic). In this article, previous studies on treatments for pain in PD are summarized according to the pain mechanisms. A mechanistic approach to treatment is discussed. We suggest that the first step should be optimizing dopaminergic therapy before other therapy is started. When these treatments remain unsuccessful, further causes of pain must be considered. The role of drugs, invasive treatments, and physiotherapeutic interventions are discussed with a focus on older PD patients and considering polypharmacy, altered pharmacokinetics, and comorbidities.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Bohlhalter, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1179-1969

Publisher:

Springer

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

30 Sep 2021 16:44

Last Modified:

30 Sep 2021 16:44

Publisher DOI:

10.1007/s40266-021-00867-1

PubMed ID:

34224103

BORIS DOI:

10.48350/159346

URI:

https://boris.unibe.ch/id/eprint/159346

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