Risk of Vaccine-Preventable Infections in Swiss Adults with Inflammatory Bowel Disease.

Pittet, Laure F; Verolet, Charlotte M; Michetti, Pierre; Gaillard, Elsa; Girardin, Marc; Juillerat, Pascal; Mottet, Christian; Maillard, Michel H; Siegrist, Claire-Anne; Posfay-Barbe, Klara M (2021). Risk of Vaccine-Preventable Infections in Swiss Adults with Inflammatory Bowel Disease. Digestion, 102(6), pp. 956-964. Karger 10.1159/000516111

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BACKGROUND

Patients with inflammatory bowel disease (IBD) have a higher risk of infection and are frequently not up to date with their immunizations.

OBJECTIVES

This study aims to review vaccination status and evaluate whether age, disease type, or treatment regimen could predict the absence of seroprotection against selected vaccine-preventable infection in adults with IBD.

METHODS

Cross-sectional study using questionnaire, immunization records review, and assessment of tetanus-specific, varicella-specific, and measles-specific immunoglobulin G concentrations. ClinicalTrials.gov: NCT01908283.

RESULTS

Among the 306 adults assessed (median age 42.7 years old, 70% with Crohn's disease, 78% receiving immunosuppressive treatment), only 33% had an immunization record available. Absence of seroprotection against tetanus (6%) was associated with increasing age and absence of booster dose; absence of seroprotection against varicella (1%) or measles (3%) was exclusively observed in younger patients with Crohn's disease. There was no statistically significant difference in immunoglobulin concentrations among treatment groups. Although vaccinations are strongly recommended in IBD patients, the frequencies of participants with at least 1 dose of vaccine recorded were low for nearly all antigens: tetanus 94%, diphtheria 87%, pertussis 54%, poliovirus 22%, measles-mumps-rubella 47%, varicella-zoster 0%, Streptococcus pneumoniae 5%, Neisseria meningitidis 12%, hepatitis A 41%, hepatitis B 48%, human papillomavirus 5%, and tick-borne encephalitis 6%.

CONCLUSIONS

Although many guidelines recommend the vaccination of IBD patients, disease prevention through immunization is still often overlooked, including in Switzerland, increasing their risk of vaccine-preventable diseases. Serological testing should be standardized to monitor patients' protection during follow-up as immunity may wane faster in this population.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology

UniBE Contributor:

Juillerat, Pascal

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0012-2823

Publisher:

Karger

Language:

English

Submitter:

Rahel Fuhrer

Date Deposited:

24 Sep 2021 10:21

Last Modified:

05 Nov 2021 00:13

Publisher DOI:

10.1159/000516111

PubMed ID:

33971650

Uncontrolled Keywords:

Crohn’s disease Immunization Ulcerative colitis Vaccine-preventable infection

BORIS DOI:

10.48350/159362

URI:

https://boris.unibe.ch/id/eprint/159362

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