Petroulia, Valentina Daphne; Brügger, Dominik; Hoepner, Robert; Vicini, Rino; Winklehner, Anna; Abegg, Mathias; Wagner, Franca (2023). MRI signs helpful in the differentiation of patients with anterior ischaemic optic neuropathy and optic neuritis. The British journal of ophthalmology, 107(1), pp. 121-126. BMJ Publishing Group 10.1136/bjophthalmol-2021-319537
Full text not available from this repository. (Request a copy)BACKGROUND/AIMS
The aim of this study was to identify specific MRI characteristics of anterior ischaemic optic neuropathy (AION) and optic neuritis (ON) that would aid in the differentiation between these two diagnoses.
METHODS
We retrospectively analysed a consecutive case series including all patients with an MRI study of brain and orbit and the clinical diagnosis of either ON or AION. We examined the scans for restricted diffusion of the optic nerve, optic sheath diameter, enhancement and location of enhancement of the optic nerve and distribution of the white matter lesions.
RESULTS
Fifty patients met the inclusion criteria. We found an accuracy of 0.98 for the discrimination between AION and ON based solely on parameters extracted from MRI data. Dominance analysis to determine the most influential parameters showed that the enhancement pattern of the optic nerve and distribution of the white matter lesions had the biggest impact on the classification and led to a discrimination accuracy of 0.9 when used alone.
CONCLUSION
In patients with an inconclusive clinical diagnosis, optic nerve enhancement pattern and distribution of white matter lesions can aid in the diagnosis and differentiation between AION and ON. Diffusion-weighted imaging did not add significant information to the diagnosis or help to differentiate between the two conditions.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology 04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology |
UniBE Contributor: |
Petroulia, Valentina Dafni, Brügger, Dominik Marcel, Hoepner, Robert, Vicini, Rino, Winklehner, Anna, Abegg, Mathias, Wagner, Franca |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1468-2079 |
Publisher: |
BMJ Publishing Group |
Language: |
English |
Submitter: |
Martin Zbinden |
Date Deposited: |
04 Oct 2021 14:46 |
Last Modified: |
17 Dec 2022 00:11 |
Publisher DOI: |
10.1136/bjophthalmol-2021-319537 |
PubMed ID: |
34281903 |
Uncontrolled Keywords: |
diagnostic tests/investigation imaging inflammation optic nerve vision |
URI: |
https://boris.unibe.ch/id/eprint/159374 |
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