MRI signs helpful in the differentiation of patients with anterior ischaemic optic neuropathy and optic neuritis.

Petroulia, Valentina Daphne; Brügger, Dominik; Hoepner, Robert; Vicini, Rino; Winklehner, Anna; Abegg, Mathias; Wagner, Franca (2021). MRI signs helpful in the differentiation of patients with anterior ischaemic optic neuropathy and optic neuritis. (In Press). The British journal of ophthalmology BMJ Publishing Group 10.1136/bjophthalmol-2021-319537

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BACKGROUND/AIMS

The aim of this study was to identify specific MRI characteristics of anterior ischaemic optic neuropathy (AION) and optic neuritis (ON) that would aid in the differentiation between these two diagnoses.

METHODS

We retrospectively analysed a consecutive case series including all patients with an MRI study of brain and orbit and the clinical diagnosis of either ON or AION. We examined the scans for restricted diffusion of the optic nerve, optic sheath diameter, enhancement and location of enhancement of the optic nerve and distribution of the white matter lesions.

RESULTS

Fifty patients met the inclusion criteria. We found an accuracy of 0.98 for the discrimination between AION and ON based solely on parameters extracted from MRI data. Dominance analysis to determine the most influential parameters showed that the enhancement pattern of the optic nerve and distribution of the white matter lesions had the biggest impact on the classification and led to a discrimination accuracy of 0.9 when used alone.

CONCLUSION

In patients with an inconclusive clinical diagnosis, optic nerve enhancement pattern and distribution of white matter lesions can aid in the diagnosis and differentiation between AION and ON. Diffusion-weighted imaging did not add significant information to the diagnosis or help to differentiate between the two conditions.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Petroulia, Valentina Dafni; Brügger, Dominik Marcel; Hoepner, Robert; Vicini, Rino; Winklehner, Anna; Abegg, Mathias and Wagner, Franca

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1468-2079

Publisher:

BMJ Publishing Group

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

04 Oct 2021 14:46

Last Modified:

04 Oct 2021 14:46

Publisher DOI:

10.1136/bjophthalmol-2021-319537

PubMed ID:

34281903

Uncontrolled Keywords:

diagnostic tests/investigation imaging inflammation optic nerve vision

URI:

https://boris.unibe.ch/id/eprint/159374

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