International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease.

Laansma, Max A; Bright, Joanna K; Al-Bachari, Sarah; Anderson, Tim J; Ard, Tyler; Assogna, Francesca; Baquero, Katherine A; Berendse, Henk W; Blair, Jamie; Cendes, Fernando; Dalrymple-Alford, John C; de Bie, Rob M A; Debove, Ines; Dirkx, Michiel F; Druzgal, Jason; Emsley, Hedley C A; Garraux, Gäetan; Guimarães, Rachel P; Gutman, Boris A; Helmich, Rick C; ... (2021). International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease. Movement disorders, 36(11), pp. 2583-2594. Wiley-Blackwell 10.1002/mds.28706

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BACKGROUND

Brain structure abnormalities throughout the course of Parkinson's disease have yet to be fully elucidated.

OBJECTIVE

Using a multicenter approach and harmonized analysis methods, we aimed to shed light on Parkinson's disease stage-specific profiles of pathology, as suggested by in vivo neuroimaging.

METHODS

Individual brain MRI and clinical data from 2357 Parkinson's disease patients and 1182 healthy controls were collected from 19 sources. We analyzed regional cortical thickness, cortical surface area, and subcortical volume using mixed-effects models. Patients grouped according to Hoehn and Yahr stage were compared with age- and sex-matched controls. Within the patient sample, we investigated associations with Montreal Cognitive Assessment score.

RESULTS

Overall, patients showed a thinner cortex in 38 of 68 regions compared with controls (dmax  = -0.20, dmin  = -0.09). The bilateral putamen (dleft  = -0.14, dright  = -0.14) and left amygdala (d = -0.13) were smaller in patients, whereas the left thalamus was larger (d = 0.13). Analysis of staging demonstrated an initial presentation of thinner occipital, parietal, and temporal cortices, extending toward rostrally located cortical regions with increased disease severity. From stage 2 and onward, the bilateral putamen and amygdala were consistently smaller with larger differences denoting each increment. Poorer cognition was associated with widespread cortical thinning and lower volumes of core limbic structures.

CONCLUSIONS

Our findings offer robust and novel imaging signatures that are generally incremental across but in certain regions specific to disease stages. Our findings highlight the importance of adequately powered multicenter collaborations.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Debove, Ines and Wiest, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0885-3185

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

04 Oct 2021 14:54

Last Modified:

18 Nov 2021 00:12

Publisher DOI:

10.1002/mds.28706

PubMed ID:

34288137

Uncontrolled Keywords:

ENIGMA MRI Parkinson's disease brain disease severity

BORIS DOI:

10.48350/159375

URI:

https://boris.unibe.ch/id/eprint/159375

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