Briner, Myriam; Oberholzer, Michael; Wagner, Franca; Chan, Andrew (2021). Potential disease trigger as a therapeutic option: infliximab for paradoxical reaction in tuberculosis of the central nervous system. BMJ case reports, 14(8) BMJ Publishing Group 10.1136/bcr-2020-235511
Full text not available from this repository.A 36-year-old man of central Asian origin was diagnosed with subacute disseminated tuberculosis. Initially, central nervous system involvement was suggested by an encephalopathic condition and MRI showing extensive basal and spinal meningitis. After initiation of anti-tuberculosis drugs and corticosteroid therapy, clinical and radiological deterioration of spinal damage was noted. We interpreted this in the context of a paradoxical reaction, which is suggested to be an overshooting inflammatory response after reconstitution of the immune system. Despite increased dosage of corticosteroids, a gradual worsening of gait ataxia over several weeks was noted. After administration of infliximab, the patient's condition progressively improved.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology 04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology |
UniBE Contributor: |
Briner, Myriam Sandra, Oberholzer, Michael, Wagner, Franca, Chan, Andrew Hao-Kuang |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1757-790X |
Publisher: |
BMJ Publishing Group |
Language: |
English |
Submitter: |
Martin Zbinden |
Date Deposited: |
01 Oct 2021 16:15 |
Last Modified: |
05 Dec 2022 15:53 |
Publisher DOI: |
10.1136/bcr-2020-235511 |
PubMed ID: |
34340991 |
Uncontrolled Keywords: |
TB and other respiratory infections immunological products and vaccines immunology infection (neurology) meningitis |
URI: |
https://boris.unibe.ch/id/eprint/159377 |
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