Arterial hypertension and proteinuria in pediatric chronic kidney disease

Simonetti, Giacomo; Bucher, Barbara; Tschumi, Sibylle; Lava, Sebastiano; Bianchetti, Mario Giovanni (2012). Arterial hypertension and proteinuria in pediatric chronic kidney disease. Minerva pediatrica, 64(2), pp. 171-82. Torino: Minerva Medica

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A variety of chronic kidney diseases tend to progress towards end-stage kidney disease. Progression is largely due to factors unrelated to the initial disease, including arterial hypertension and proteinuria. Intensive treatment of these two factors is potentially able to slow the progression of kidney disease. Blockers of the renin-angiotensin-aldosterone system, either converting enzyme inhibitors or angiotensin II receptor antagonists, reduce both blood pressure and proteinuria and appear superior to a conventional antihypertensive treatment regimen in preventing progression to end-stage kidney disease. The most recent recommendations state that in children with chronic kidney disease without proteinuria the blood pressure goal is the corresponding 75th centile for body length, age and gender; whereas the 50th centile should be aimed in children with chronic kidney disease and pathologically increased proteinuria.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
UniBE Contributor:	Simonetti, Giacomo, Bucher, Barbara, Tschumi, Sibylle, Lava, Sebastiano, Bianchetti, Mario Giovanni
Subjects:	600 Technology > 610 Medicine & health
ISSN:	0026-4946
ISBN:	0026-4946
Publisher:	Minerva Medica
Language:	English
Submitter:	Anette van Dorland
Date Deposited:	04 Oct 2013 14:39
Last Modified:	05 Dec 2022 14:12
PubMed ID:	22495191
Web of Science ID:	000315477900005
URI:	https://boris.unibe.ch/id/eprint/15956 (FactScience: 223467)