Lincke, Joel-Benjamin; Dysli, Chantal; Jaggi, Damian; Solberg, Yasmin; Wolf, Sebastian; Zinkernagel, Martin (2021). Longitudinal foveal fluorescence lifetime characteristics in geographic atrophy using fluorescence lifetime imaging ophthalmoscopy (FLIO). Retina, 41(11), pp. 2391-2398. Wolters Kluwer 10.1097/IAE.0000000000003222
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PURPOSE
Short foveal fluorescence lifetimes (fFLT) in geographic atrophy are typically found in eyes with foveal sparing (FS) but may also occur in eyes without FS. We investigated whether short fFLT could serve as a functional biomarker for disease progression in geographic atrophy (GA).
METHODS
Thirty three eyes were followed over the course of 4-6 years. FS was assessed using fluorescence lifetime imaging ophthalmoscopy, OCT, FAF and macular pigment optical density.
RESULTS
Eyes with FS exhibited shorter fFLT compared to eyes without FS. Short fFLT (<600ps) were measured in all eyes with FS and half of the eyes without FS. Eyes with FS showed a bigger increase in fFLT per year (+39/+30 ps (SSC/LSC) in FS vs. +29/+22 ps (SSC/LSC) in non FS). BCVA correlated significantly with fFLT (p=0.018 and p=0.005 for SSC/LSC). MPOD measurements correlated significantly with fFLT but not in all spectral channels (p ranging from 0.018 to 0.077).
CONCLUSION
In GA, shorter fFLT are associated with foveal sparing but they can also be observed in eyes without FS. Our longitudinal data suggests that shorter fFLT features in eyes with loss of FS represent an earlier stage of disease and may be more prone to loss of visual acuity.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
UniBE Contributor: |
Lincke, Joel-Benjamin, Dysli, Chantal-Simone, Jaggi, Damian, Solberg, Yasmin Samira, Wolf, Sebastian (B), Zinkernagel, Martin Sebastian |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1539-2864 |
Publisher: |
Wolters Kluwer |
Language: |
English |
Submitter: |
Sebastian Wolf |
Date Deposited: |
07 Oct 2021 15:38 |
Last Modified: |
05 Dec 2022 15:53 |
Publisher DOI: |
10.1097/IAE.0000000000003222 |
PubMed ID: |
34282069 |
BORIS DOI: |
10.48350/159567 |
URI: |
https://boris.unibe.ch/id/eprint/159567 |
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