Thromboembolic complications in autoimmune hemolytic anemia.

Holzer-Schär, Deborah Tabita; Daskalakis, Michael; Mansouri, Behrouz; Rovó, Alicia; Zeerleder, Sacha (2021). Thromboembolic complications in autoimmune hemolytic anemia. (In Press). European journal of haematology Wiley-Blackwell 10.1111/ejh.13710

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INTRODUCTION

A small number of retrospective studies suggest AIHA to be associated with an increased risk to suffer from thromboembolic events. However, based on these studies it remains unclear on whether the complement activation per is a risk factor to develop thromboembolic events in AIHA patients. The aim of this retrospective study is to investigate the incidence of thromboembolic events and the relation to complement activation in a cohort of AIHA patients.

PATIENTS & METHODS

We included 77 patients in this study with a positive DAT and hemolytic parameters or with AIHA diagnosis based on the medical report. The included patients were screened for thromboembolic events (TEE) and have been stratified in groups with and without complement activation based on the positivity for complement in the DAT.

RESULTS

Of the 77 included patients 51(66%) had warm-AIHA, 13 (17%) cold-AIHA, 5 (7%) mixed AIHA and 8 (10%) atypical AIHA, respectively. Primary and secondary AIHA was diagnosed in 44% and 56%, respectively. Twenty patients (26%) suffered from TEE. The majority (80%) of these patients suffered from warm-AIHA and 10% from cold-AIHA. Hemolysis parameters did not differ in patients with and without TEE. There was no correlation with complement activation as evidenced by a positivity for complement in the monospecific DAT with the occurrence of TEE.

CONCLUSION

AIHA is associated with an increased risk of TEE. Based on these results prophylactic anticoagulation might be considered as soon as the diagnosis of AIHA is confirmed.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Hämatologie (Erwachsene)

UniBE Contributor:

Daskalakis, Michael; Mansouri Taleghani, Behrouz; Rovó, Alicia and Zeerleder, Sacha Sergio

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0902-4441

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Pierrette Durand Lüthi

Date Deposited:

08 Oct 2021 13:41

Last Modified:

08 Oct 2021 13:41

Publisher DOI:

10.1111/ejh.13710

PubMed ID:

34551149

BORIS DOI:

10.48350/159569

URI:

https://boris.unibe.ch/id/eprint/159569

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