Systematic Review of Outcome Measures Used in Observational Studies of Adults with Eosinophilic Esophagitis.

Schoepfer, Alain M; Schürmann, Camilla; Trelle, Sven; Zwahlen, Marcel; Ma, Christopher; Chehade, Mirna; Dellon, Evan S; Jairath, Vipul; Feagan, Brian G; Bredenoord, Albert J; Biedermann, Luc; Greuter, Thomas; Schreiner, Philipp; Straumann, Alex; Safroneeva, Ekaterina (2021). Systematic Review of Outcome Measures Used in Observational Studies of Adults with Eosinophilic Esophagitis. International archives of allergy and immunology, 182(12), pp. 1169-1193. Karger 10.1159/000516898

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BACKGROUND

Over the last 20 years, diverse outcome measures have been used to evaluate the effectiveness of therapies for eosinophilic esophagitis (EoE). This systematic review aims to identify the readouts used in observational studies of topical corticosteroids, diet, and dilation in adult EoE patients.

METHODS

We searched MEDLINE and Embase for prospective and retrospective studies (cohorts/case series, randomized open-label, and case-control) evaluating the use of diets, dilation, and topical corticosteroids in adults with EoE. Two authors independently assessed the articles and extracted information about histologic, endoscopic, and patient-reported outcomes and tools used to assess treatment effects.

RESULTS

We included 69 studies that met inclusion criteria. EoE-associated endoscopic findings (assessed either as absence/presence or using Endoscopic Reference Score) were evaluated in 24/35, 11/17, and 9/17 studies of topical corticosteroids, diet, and dilation, respectively. Esophageal eosinophil density was recorded in 32/35, 17/17, and 11/17 studies of topical corticosteroids, diet, and dilation, respectively. Patient-reported outcomes were not uniformly used (only in 14, 8, and 3 studies of topical corticosteroids, diet, and dilation, respectively), and most tools were not validated for use in adults with EoE.

CONCLUSIONS

Despite the lack of an agreed set of core outcomes that should be recorded and reported in studies in adult EoE patients, endoscopic EoE-associated findings and esophageal eosinophil density are commonly used to assess disease activity in observational studies. Standardization of outcomes and data supporting the use of outcomes are needed to facilitate interpretation of evidence, its synthesis, and comparisons of interventions in meta-analyses of therapeutic trials in adults with EoE.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Pre-clinic Human Medicine > Department of Clinical Research (DCR)

UniBE Contributor:

Trelle, Sven, Zwahlen, Marcel, Safroneeva, Ekaterina

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1018-2438

Publisher:

Karger

Language:

English

Submitter:

Andrea Flükiger-Flückiger

Date Deposited:

08 Oct 2021 10:49

Last Modified:

20 Feb 2024 14:16

Publisher DOI:

10.1159/000516898

PubMed ID:

34544078

Uncontrolled Keywords:

Corticosteroids Diet Dilation Eosinophilic esophagitis Outcomes Systematic review

BORIS DOI:

10.48350/159687

URI:

https://boris.unibe.ch/id/eprint/159687

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