Insular volume abnormalities associated with different transition probabilities to psychosis

Smieskova, R; Fusar-Poli, P; Aston, J; Simon, A; Bendfeldt, K; Lenz, C; Stieglitz, R D; McGuire, P; Riecher-Rössler, A; Borgwardt, S J (2012). Insular volume abnormalities associated with different transition probabilities to psychosis. Psychological medicine, 42(08), pp. 1613-1625. Cambridge: Cambridge University Press 10.1017/s0033291711002716

[img] Text
download.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (211kB) | Request a copy
S0033291711002716.pdf - Other
Available under License Publisher holds Copyright.

Download (236kB) | Preview

Background Although individuals vulnerable to psychosis show brain volumetric abnormalities, structural alterations underlying different probabilities for later transition are unknown. The present study addresses this issue by means of voxel-based morphometry (VBM).

Method We investigated grey matter volume (GMV) abnormalities by comparing four neuroleptic-free groups: individuals with first episode of psychosis (FEP) and with at-risk mental state (ARMS), with either long-term (ARMS-LT) or short-term ARMS (ARMS-ST), compared to the healthy control (HC) group. Using three-dimensional (3D) magnetic resonance imaging (MRI), we examined 16 FEP, 31 ARMS, clinically followed up for on average 3 months (ARMS-ST, n=18) and 4.5 years (ARMS-LT, n=13), and 19 HC.

Results The ARMS-ST group showed less GMV in the right and left insula compared to the ARMS-LT (Cohen's d 1.67) and FEP groups (Cohen's d 1.81) respectively. These GMV differences were correlated positively with global functioning in the whole ARMS group. Insular alterations were associated with negative symptomatology in the whole ARMS group, and also with hallucinations in the ARMS-ST and ARMS-LT subgroups. We found a significant effect of previous antipsychotic medication use on GMV abnormalities in the FEP group.

Conclusions GMV abnormalities in subjects at high clinical risk for psychosis are associated with negative and positive psychotic symptoms, and global functioning. Alterations in the right insula are associated with a higher risk for transition to psychosis, and thus may be related to different transition probabilities.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management

UniBE Contributor:

Simon, Andor




Cambridge University Press




Factscience Import

Date Deposited:

04 Oct 2013 14:39

Last Modified:

28 Oct 2019 03:12

Publisher DOI:


Web of Science ID:




URI: (FactScience: 223513)

Actions (login required)

Edit item Edit item
Provide Feedback