Placebo effect characteristics observed in a single, international, longitudinal study in Huntington's disease

Cubo, E.; Gonzáles, M.; del Puerto, I.; de Yébenes, J. G.; Arconada, O. F.; Gabriel y Galàn, J. .M; Nirkko, Arto Christian; European Huntington's Disease Initiative Study Group, (2012). Placebo effect characteristics observed in a single, international, longitudinal study in Huntington's disease. Movement disorders, 2012(27), pp. 439-442. Hoboken, N.J.: Wiley-Blackwell 10.1002/mds.24062

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BACKGROUND Classically, clinical trials are based on the placebo-control design. Our aim was to analyze the placebo effect in Huntington's disease. METHODS Placebo data were obtained from an international, longitudinal, placebo-controlled trial for Huntington's disease (European Huntington's Disease Initiative Study Group). One-hundred and eighty patients were evaluated using the Unified Huntington Disease Rating Scale over 36 months. A placebo effect was defined as an improvement of at least 50% over baseline scores in the Unified Huntington Disease Rating Scale, and clinically relevant when at least 10% of the population met it. RESULTS Only behavior showed a significant placebo effect, and the proportion of the patients with placebo effect ranged from 16% (first visit) to 41% (last visit). Nondepressed patients with better functional status were most likely to be placebo-responders over time. CONCLUSIONS In Huntington's disease, behavior seems to be more vulnerable to placebo than overall motor function, cognition, and function

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Nirkko, Arto Christian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0885-3185

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:39

Last Modified:

20 Dec 2014 11:25

Publisher DOI:

10.1002/mds.24062

Web of Science ID:

000301339300020

Uncontrolled Keywords:

clinical trials, Huntington's disease, movement disorders, placebo

BORIS DOI:

10.7892/boris.16011

URI:

https://boris.unibe.ch/id/eprint/16011 (FactScience: 223554)

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