Hunziker, E. B.; Liu, Y.; Muff, M.; Haegi, T.; Shintani, N.; Lippuner, K. (2021). The slow release of BMP-7 at a low dose accelerates dental implant healing in an osteopenic environment. European cells & materials eCM, 41, pp. 170-183. University of Wales 10.22203/eCM.v041a12
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The aim of the present study was to investigate in vivo whether bone morphogenetic protein-7 (BMP-7) was able to promote and accelerate dental implant healing at a low dose in an osteopenic environment by using a delayed drug-release system. Skeletally mature Chinese goats, having physiologically osteopenic (osteoporotic-like) facial bones, served as an animal model. Dental implants were provided with a delayed-release drug-delivery system and BMP-7 was applied at three different dosages. The implants, inserted into healed extraction sockets, were removed 1, 2 and 3 weeks after surgery. Quantification of osseointegration and formation of new bone in the peri- implant space were measured histomorphometrically. Data revealed no evidence of any adverse drug effect at or near the implantation sites. After the first postoperative week, bone neoformation was minimal; after the second week, peri-implant bone formation appeared, particularly in the groups with low dosages of BMP-7. After 3 weeks, new-bone volume was the largest in the group with the lowest (near-physiological) dosage of BMP-7, also showing the highest efficacy of BMP-7. Other dosage or release modes were found to be significantly less effective. BMP-7 was highly efficacious in promoting and accelerating bone formation in the peri-implant space in a hostile osteopenic environment if released by a slow-mode mechanism over time at near physiological activities. Therefore, biological functionalisation of dental implants by a high-power osteogenic factor may improve their healing success in hostile bony environments (osteopenia, osteoporosis, bone atrophy etc.).
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Osteoporosis 04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Orthopaedic Surgery |
UniBE Contributor: |
Hunziker, Ernst Bruno, Liu, Yuelian, Lippuner, Kurt |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1473-2262 |
Publisher: |
University of Wales |
Language: |
English |
Submitter: |
Kathrin Aeschlimann |
Date Deposited: |
10 Nov 2021 17:19 |
Last Modified: |
05 Dec 2022 15:53 |
Publisher DOI: |
10.22203/eCM.v041a12 |
PubMed ID: |
33580967 |
BORIS DOI: |
10.48350/160117 |
URI: |
https://boris.unibe.ch/id/eprint/160117 |
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