Pflüger, Michael J; Maurer, Max M; Hillebrandt, Karl H; Andreou, Andreas; Geisel, Dominik; Schmelzle, Moritz; Pratschke, Johann; Eurich, Dennis (2021). Intrahepatic De Novo Tumors in Liver Recipients are Highly Associated With Recurrent Viral Hepatitis. Journal of clinical and experimental hepatology, 11(4), pp. 435-442. Elsevier 10.1016/j.jceh.2020.11.003
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Background/Aims
Long-term survival of liver transplant recipients is endangered by tumorigenesis at different sites. Little is known about primary de novo tumors developing in the graft.
Methods
We analyzed the follow-up data of 2731 liver recipients that were transplanted between 1988 and 2019 at our institution (Charité - Universitätsmedizin Berlin, Department of Surgery). All cases with new intrahepatic tumors during follow-up were identified.
Results
A total of nine patients were diagnosed at a median of 16 years (range, 2-24 years) after surgery. Eight patients presented with hepatocellular carcinoma (HCC), and one patient presented with epithelioid hemangioendothelioma (EHE). All eight HCC patients had a recurrence of the initial disease that had caused liver failure before transplantation. This was associated with viral reinfection with either HCV or HBV in seven cases. Of the nine patients, three underwent surgical resection and only one patient was alive at data abstraction.
Conclusion
Intrahepatic de novo neoplasms in the liver graft need to be considered in the long-term follow-up of liver recipients and were strongly associated with recurrent viral hepatitis in our study. Although prognosis of this rare complication is generally poor, patients may benefit from surgical resection of localized disease.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine |
UniBE Contributor: |
Andreou, Andreas |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0973-6883 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Rahel Fuhrer |
Date Deposited: |
26 Oct 2021 17:24 |
Last Modified: |
05 Dec 2022 15:53 |
Publisher DOI: |
10.1016/j.jceh.2020.11.003 |
PubMed ID: |
34276150 |
Uncontrolled Keywords: |
AFP, alpha-fetoprotein ALF, acute liver failure CA 19-9, carbohydrate antigen 19-9 CCA, cholangiocarcinoma CEA, carcinoembryonic antigen DCV, daclatasvir EHE, epithelioid hemangioendothelioma ESLD, end-stage liver disease HBIG, hepatitis B immune globulin HBsAg, hepatitis B surface antigen HCC, hepatocellular carcinoma IS, immunosuppressive therapy LT, liver transplantation NUCs, nucleos(t)ide analogues PSC, primary sclerosing cholangitis PTLD, post-transplantation lymphoproliferative disorder PegIFN, pegylated interferon RBV, ribavirin SOF, sofosbuvir SVR, sustained viral response epithelioid hemangioendothelioma hepatocellular carcinoma liver transplant long-term survival surgical resection |
BORIS DOI: |
10.48350/160144 |
URI: |
https://boris.unibe.ch/id/eprint/160144 |
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