Prefrontal and striatal dopamine D2/D3 receptors correlate with fMRI BOLD activation during stopping

Pfeifer, Philippe; Sebastian, Alexandra; Buchholz, Hans Georg; Kaller, Christoph P.; Gründer, Gerhard; Fehr, Christoph; Schreckenberger, Mathias; Tüscher, Oliver (2021). Prefrontal and striatal dopamine D2/D3 receptors correlate with fMRI BOLD activation during stopping. Brain imaging and behavior, 16(1), pp. 186-198. Springer 10.1007/s11682-021-00491-y

Preview

Text pfeifer_dopamineD2_fMRI_PET_stopping_Brain_Image_Behav_2021.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview

D2-like dopamine receptors in animals and humans have been shown to be linked to impulsive behaviors that are highly relevant for several psychiatric disorders. Here, we investigate the relationship between the fronto-striatal D2/D3 dopamine receptor availability and response inhibition in a selected population of healthy OPRM1 G-allele carriers. Twenty-two participants successively underwent blood-oxygen level dependent functional magnetic resonance imaging (fMRI) while performing a stop-signal task and a separate positron emission tomography (PET) scan. Striatal and extrastriatal D2/D3 dopamine receptor availability was measured using the radiotracer [18F]fallypride. Caudate D2/D3 dopamine receptor availability positively correlated with stopping-related fronto-striatal fMRI activation. In addition, right prefrontal D2/D3 dopamine receptor availability correlated positively with stopping-related striatal fMRI BOLD signal. Our study partially replicates previous findings on correlations between striatal D2/D3 dopamine receptor availability and response inhibition in a population selected for its genetic determination of dopamine response to alcohol and as a modulator of impulse control via the endogenous opioid system. We confirm the important role of D2/D3 dopamine receptor availability in the fronto-striatal neural circuit for response inhibition. Moreover, we extend previous findings suggesting that dopamine receptor availability in the right inferior frontal cortex, a crucial region of the stopping network, is also strongly associated with stopping-related striatal fMRI activity in healthy OPRM1 G-allele carriers.

Interest & Impact

Downloads

54 since deposited on 05 Nov 2021
15 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item