Prefrontal and striatal dopamine D2/D3 receptors correlate with fMRI BOLD activation during stopping

Pfeifer, Philippe; Sebastian, Alexandra; Buchholz, Hans Georg; Kaller, Christoph P.; Gründer, Gerhard; Fehr, Christoph; Schreckenberger, Mathias; Tüscher, Oliver (2021). Prefrontal and striatal dopamine D2/D3 receptors correlate with fMRI BOLD activation during stopping. Brain imaging and behavior, 16(1), pp. 186-198. Springer 10.1007/s11682-021-00491-y

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D2-like dopamine receptors in animals and humans have been shown to be linked to impulsive behaviors that are highly relevant for several psychiatric disorders. Here, we investigate the relationship between the fronto-striatal D2/D3 dopamine receptor availability and response inhibition in a selected population of healthy OPRM1 G-allele carriers. Twenty-two participants successively underwent blood-oxygen level dependent functional magnetic resonance imaging (fMRI) while performing a stop-signal task and a separate positron emission tomography (PET) scan. Striatal and extrastriatal D2/D3 dopamine receptor availability was measured using the radiotracer [18F]fallypride. Caudate D2/D3 dopamine receptor availability positively correlated with stopping-related fronto-striatal fMRI activation. In addition, right prefrontal D2/D3 dopamine receptor availability correlated positively with stopping-related striatal fMRI BOLD signal. Our study partially replicates previous findings on correlations between striatal D2/D3 dopamine receptor availability and response inhibition in a population selected for its genetic determination of dopamine response to alcohol and as a modulator of impulse control via the endogenous opioid system. We confirm the important role of D2/D3 dopamine receptor availability in the fronto-striatal neural circuit for response inhibition. Moreover, we extend previous findings suggesting that dopamine receptor availability in the right inferior frontal cortex, a crucial region of the stopping network, is also strongly associated with stopping-related striatal fMRI activity in healthy OPRM1 G-allele carriers.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy

UniBE Contributor:

Pfeifer, Philippe

Subjects:

600 Technology > 610 Medicine & health
600 Technology > 610 Medicine & health > 615 Pharmacology & therapeutics, prescription drugs

ISSN:

1931-7557

Publisher:

Springer

Language:

English

Submitter:

Philippe Pfeifer

Date Deposited:

05 Nov 2021 09:20

Last Modified:

05 Dec 2022 15:53

Publisher DOI:

10.1007/s11682-021-00491-y

PubMed ID:

34403039

BORIS DOI:

10.48350/160177

URI:

https://boris.unibe.ch/id/eprint/160177

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