Physical coronary arteriogenesis: a human "model" of collateral growth promotion

Vogel, Rolf; Traupe, Tobias; Stolt Steiger, Valérie; Seiler, Christian (2010). Physical coronary arteriogenesis: a human "model" of collateral growth promotion. Trends in cardiovascular medicine, 20(4), pp. 129-133. New York, N.Y.: Elsevier 10.1016/j.tcm.2010.10.004

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In patients with coronary artery disease, the size of myocardial infarction mainly determines the subsequent clinical outcome. Accordingly, it is the primary strategy to decrease cardiovascular mortality by minimizing infarct size. Promotion of collateral artery growth (arteriogenesis) is an appealing option of reducing infarct size. It has been demonstrated in experimental models that tangential fluid shear stress is the major trigger of arterial remodeling and, thus, of collateral growth. Lower-leg, high-pressure external counterpulsation triggered to occur during diastole induces a flow velocity signal and thus tangential endothelial shear stress in addition to the flow signal caused by cardiac stroke volume. We here present two cases of cardiac transplant recipients as human "models" of physical coronary arteriogenesis, providing an example of progressing and regressing clinical arteriogenesis, and review available evidence from clinical studies on other feasible forms of physical arteriogenesis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Cardiovascular Engineering (CVE)

UniBE Contributor:

Vogel, Rolf; Traupe, Tobias; Stolt Steiger, Valerie and Seiler, Christian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1050-1738

Publisher:

Elsevier

Language:

English

Submitter:

Francesco Clavica

Date Deposited:

04 Oct 2013 14:10

Last Modified:

09 Dec 2014 12:09

Publisher DOI:

10.1016/j.tcm.2010.10.004

PubMed ID:

21335283

Web of Science ID:

000287993500005

BORIS DOI:

10.7892/boris.1602

URI:

https://boris.unibe.ch/id/eprint/1602 (FactScience: 203379)

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