Management and outcomes in critically ill nonagenarian versus octogenarian patients.

Bruno, Raphael Romano; Wernly, Bernhard; Kelm, Malte; Boumendil, Ariane; Morandi, Alessandro; Andersen, Finn H; Artigas, Antonio; Finazzi, Stefano; Cecconi, Maurizio; Christensen, Steffen; Faraldi, Loredana; Lichtenauer, Michael; Muessig, Johanna M; Marsh, Brian; Moreno, Rui; Oeyen, Sandra; Öhman, Christina Agvald; Pinto, Bernardo Bollen; Soliman, Ivo W; Szczeklik, Wojciech; ... (2021). Management and outcomes in critically ill nonagenarian versus octogenarian patients. BMC Geriatrics, 21(1), p. 576. BioMed Central 10.1186/s12877-021-02476-4

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BACKGROUND

Intensive care unit (ICU) patients age 90 years or older represent a growing subgroup and place a huge financial burden on health care resources despite the benefit being unclear. This leads to ethical problems. The present investigation assessed the differences in outcome between nonagenarian and octogenarian ICU patients.

METHODS

We included 7900 acutely admitted older critically ill patients from two large, multinational studies. The primary outcome was 30-day-mortality, and the secondary outcome was ICU-mortality. Baseline characteristics consisted of frailty assessed by the Clinical Frailty Scale (CFS), ICU-management, and outcomes were compared between octogenarian (80-89.9 years) and nonagenarian (> 90 years) patients. We used multilevel logistic regression to evaluate differences between octogenarians and nonagenarians.

RESULTS

The nonagenarians were 10% of the entire cohort. They experienced a higher percentage of frailty (58% vs 42%; p < 0.001), but lower SOFA scores at admission (6 + 5 vs. 7 + 6; p < 0.001). ICU-management strategies were different. Octogenarians required higher rates of organ support and nonagenarians received higher rates of life-sustaining treatment limitations (40% vs. 33%; p < 0.001). ICU mortality was comparable (27% vs. 27%; p = 0.973) but a higher 30-day-mortality (45% vs. 40%; p = 0.029) was seen in the nonagenarians. After multivariable adjustment nonagenarians had no significantly increased risk for 30-day-mortality (aOR 1.25 (95% CI 0.90-1.74; p = 0.19)).

CONCLUSION

After adjustment for confounders, nonagenarians demonstrated no higher 30-day mortality than octogenarian patients. In this study, being age 90 years or more is no particular risk factor for an adverse outcome. This should be considered- together with illness severity and pre-existing functional capacity - to effectively guide triage decisions.

TRIAL REGISTRATION

NCT03134807 and NCT03370692 .

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Schefold, Jörg Christian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1471-2318

Publisher:

BioMed Central

Language:

English

Submitter:

Jsabelle Arni

Date Deposited:

03 Nov 2021 16:48

Last Modified:

07 Nov 2021 01:41

Publisher DOI:

10.1186/s12877-021-02476-4

PubMed ID:

34666709

Uncontrolled Keywords:

Frailty Intensive care medicine Nonagenarians Octogenarians Outcome

BORIS DOI:

10.48350/160268

URI:

https://boris.unibe.ch/id/eprint/160268

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