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Schoepfer\054 Philipp Schreiner\054 Frank Seibold\054 Mariam Seirafi\054 Gian\055Marco Semadeni\054 Arne ) Tj T* (Senning\054 Christiane Sokollik\054 Joachim Sommer\054 Johannes Spalinger\054 Holger Spangenberger\054 Philippe Stadler\054 Peter Staub\054 ) Tj T* (Dominic Staudenmann\054 Volker Stenz\054 Michael Steuerwald\054 Alex Straumann\054 Andreas Stulz\054 Michael Sulz\054 Michela Tempia\055) Tj T* (Caliera\054 Jo\353l Thorens\054 Kaspar Truninger\054 Radu Tutuian\054 Patrick Urfer\054 Stephan Vavricka\054 Francesco Viani\054 Fabrizion Vinzens\054 ) Tj T* (J\374rg V\366gtlin\054 Roland Von K\344nel\054 Dominique Vouillamoz\054 Rachel Vulliamy\054 Marianne Vulli\350moz\054 Paul Wiesel\054 Reiner Wiest\054 ) Tj T* (Stefanie W\366hrle\054 Bahtiyar Yilmaz\054 Samuel Zamora\054 Silvan Zander\054 Jonas Zeitz\054 Dorothee Zimmermann\056) Tj /T1_3 1 Tf 10.5 0 0 10.5 42.5197 223.6971 Tm [ (Abstr) -3 (act) ] TJ /T1_2 1 Tf 0 -1.238 TD (Background and aims\072) Tj /T1_0 1 Tf ( Anxiety and depression are prevalent in patients with inflammatory ) Tj 0 -1.238 TD (bowel diseases \050IBD\051\054 especially during IBD flares\056 IBD therapies can profoundly affect ) Tj 0 -1.238 TD (the mood of patients with IBD\056 We aimed to determine the long\055term impact of anti\055tumor ) Tj 0 -1.238 TD (necrosis factor \050anti\055TNF\051 and immunomodulators \050IM\051 on anxiety and depressive symptoms ) Tj 0 -1.238 TD (in IBD patients\056) Tj /T1_2 1 Tf 0 -1.238 TD (Methods\072) Tj /T1_0 1 Tf ( We compared three treatment groups with IM only \050group A\051\054 anti\055TNF) Tj /Span << /ActualText (\376\377 \011) >> BDC ( ) Tj EMC /T1_4 1 Tf 35.659 0 Td (\037) Tj /T1_0 1 Tf -0.124 Tw /Span << /ActualText (\376\377 \011) >> BDC ( ) Tj EMC [ (IM ) -124 (\050group ) ] TJ 0 Tw -35.659 -1.238 Td (B\051 and no such therapy \050group C\051\056 Patients completed the hospital anxiety and depression ) Tj T* (scale \050HADS\051 at 1) Tj /Span << /ActualText (\376\377 \011) >> BDC ( ) Tj EMC 7.755 0 Td (year\054 3) Tj /Span << /ActualText (\376\377 \011) >> BDC ( ) Tj EMC 3.084 0 Td (years\054 and 5) Tj /Span << /ActualText (\376\377 \011) >> BDC ( ) Tj EMC 5.462 0 Td (years after start of treatment\056) Tj /T1_2 1 Tf -16.301 -1.238 Td (Results\072) Tj /T1_0 1 Tf ( In total\054 581 patients with IBD \05042\0569\045 Crohn\222s disease\054 57\0561\045 ulcerative colitis\057IBD ) Tj T* (unclassified\051 participated in this study\056 Effects of treatment were analyzed in a mixed effects ) Tj 0 -1.238 TD (model\054 with and without correction for confounders\056 Compared with group C\054 group B showed ) Tj 6.5 0 0 6.5 491.7638 490.5748 Tm (Correspondence to\072) Tj /Span << /ActualText (\376\377\000\011) >> BDC ( ) Tj EMC 0.85 0.17 0.76 0.57 k /GS0 gs /T1_2 1 Tf 0 -1.231 TD (Alexander R\056 Siebenh\374ner) Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf ( ) Tj T* (Department of Medical ) Tj T* (Oncology and Hematology\054 ) Tj T* (University Hospital Zurich ) Tj T* (and University of Zurich\054 ) Tj T* (R\344mistrasse 100\054 Zurich\054 ) Tj 0 -1.231 TD (CH\0558091\054 Switzerland ) Tj 0 -1.692 TD (Department of ) Tj 0 -1.231 TD (Gastroenterology and ) Tj T* (Hepatology\054 University ) Tj T* (Hospital Zurich and ) Tj T* (University of Zurich\054 ) Tj T* (Zurich\054 Switzerland ) Tj 0.85 0.17 0.76 0.57 k /GS0 gs /T1_2 1 Tf T* (alexander\056siebenhuener\100) Tj T* (usz\056ch) Tj 0 0 0 1 k /GS1 gs 0 -1.692 TD (Jean\055Beno\356t Rossel) Tj /T1_0 1 Tf ( ) Tj 0 -1.231 TD (Center for Primary ) Tj T* (Care and Public Health ) Tj T* (\050Unisant\351\051\054 University ) Tj T* (of Lausanne\054 Lausanne\054 ) Tj T* (Vaud\054 Switzerland) Tj /T1_2 1 Tf 0 -1.692 TD (Philipp Schreiner) Tj 0 -1.231 Td (Matthias Butter) Tj 0 -1.231 TD (Thomas Greuter) Tj 0 -1.231 Td (Luc Biedermann) Tj T* (Gerhard Rogler) Tj /T1_0 1 Tf ( ) Tj 0 -1.231 TD (Department of ) Tj 0 -1.231 TD (Gastroenterology and ) Tj T* (Hepatology\054 University ) Tj T* (Hospital Zurich and ) Tj T* (University of Zurich\054 ) Tj T* (Zurich\054 Switzerland) Tj /T1_2 1 Tf 0 -1.692 TD (Niklas Krupka) Tj 0 -1.231 TD (Sebastian B\056 U\056 Jordi) Tj T* (Benjamin Misselwitz) Tj /T1_0 1 Tf ( ) Tj T* (Department of Visceral ) Tj T* (Surgery and Medicine\054 ) Tj 0 -1.231 TD (Inselspital Bern and ) Tj 0 -1.231 TD (Bern University\054 Bern\054 ) Tj T* (Switzerland) Tj /T1_2 1 Tf 0 -1.692 TD (Roland von K\344nel) Tj /T1_0 1 Tf ( ) Tj 0 -1.231 TD (Department of ) Tj T* (Consultation\055Liaison ) Tj T* (Psychiatry and ) Tj T* (Psychosomatic Medicine\054 ) Tj T* (University Hospital Zurich\054 ) Tj T* (Switzerland) Tj 0 -1.692 TD (\052Equal contribution as ) Tj ( ) Tj 0 -1.231 TD (last authors) Tj ET 0 0 0 0 k /GS0 gs 7.559 775.66 466.299 9 re f BT /T1_5 1 Tf 0.025 Tc -0.025 Tw 9.5 0 0 9.5 7.5591 783.6597 Tm (1033763) Tj /T1_0 1 Tf -0.06 Tc 0.06 Tw 1 0 0 1 42.4716 783.6597 Tm [ (TA) -50 (G) ] TJ ET q 0 0 595.276 793.701 re W n 0 0 0 0 K 2 w 4 M q 1 0 0 1 44.2595 783.9658 cm 0 0 m 0 -0.084 0.019 -0.156 0.06 -0.218 c 0.104 -0.285 0.159 -0.318 0.225 -0.318 c 0.294 -0.318 0.352 -0.278 0.395 -0.203 c 0.434 -0.133 0.454 -0.05 0.454 0.037 c 0.454 0.222 0.359 0.358 0.228 0.358 c 0.1 0.358 0 0.199 0 0 c h 0.094 0.06 m 0.094 0.148 0.101 0.194 0.12 0.239 c 0.139 0.285 0.177 0.315 0.216 0.315 c 0.308 0.315 0.36 0.198 0.36 -0.012 c 0.36 -0.093 0.352 -0.146 0.334 -0.195 c 0.315 -0.248 0.276 -0.281 0.233 -0.281 c 0.197 -0.281 0.164 -0.258 0.143 -0.216 c 0.125 -0.181 0.113 -0.146 0.107 -0.111 c 0.099 -0.061 0.094 -0.001 0.094 0.06 c h S Q Q BT /T1_6 1 Tf 0 Tc 0 Tw 44.211 783.66 Td (0) Tj ET q 0 0 595.276 793.701 re W n 0 0 0 0 K 2 w 4 M q 1 0 0 1 44.8115 783.9658 cm 0 0 m 0 -0.084 0.019 -0.156 0.06 -0.218 c 0.104 -0.285 0.159 -0.318 0.225 -0.318 c 0.294 -0.318 0.352 -0.278 0.395 -0.203 c 0.434 -0.133 0.454 -0.05 0.454 0.037 c 0.454 0.222 0.359 0.358 0.228 0.358 c 0.1 0.358 0 0.199 0 0 c h 0.094 0.06 m 0.094 0.148 0.101 0.194 0.12 0.239 c 0.139 0.285 0.177 0.315 0.216 0.315 c 0.308 0.315 0.36 0.198 0.36 -0.012 c 0.36 -0.093 0.352 -0.146 0.334 -0.195 c 0.315 -0.248 0.276 -0.281 0.233 -0.281 c 0.197 -0.281 0.164 -0.258 0.143 -0.216 c 0.125 -0.181 0.113 -0.146 0.107 -0.111 c 0.099 -0.061 0.094 -0.001 0.094 0.06 c h S Q Q BT /T1_6 1 Tf 44.763 783.66 Td (0) Tj ET q 0 0 595.276 793.701 re W n 0 0 0 0 K 2 w 4 M q 1 0 0 1 45.6415 784.3237 cm 0 0 m -0.029 0 l -0.078 -0.038 -0.119 -0.051 -0.19 -0.051 c -0.19 -0.087 l -0.173 -0.087 l -0.115 -0.087 -0.094 -0.115 -0.094 -0.169 c -0.094 -0.537 l -0.094 -0.598 -0.12 -0.628 -0.177 -0.628 c -0.193 -0.628 l -0.193 -0.664 l 0.091 -0.664 l 0.091 -0.628 l 0.081 -0.628 l 0.022 -0.628 0 -0.595 0 -0.534 c h S Q q 1 0 0 1 45.9155 783.9658 cm 0 0 m 0 -0.084 0.019 -0.156 0.06 -0.218 c 0.104 -0.285 0.159 -0.318 0.225 -0.318 c 0.294 -0.318 0.352 -0.278 0.395 -0.203 c 0.434 -0.133 0.454 -0.05 0.454 0.037 c 0.454 0.222 0.359 0.358 0.228 0.358 c 0.1 0.358 0 0.199 0 0 c h 0.094 0.06 m 0.094 0.148 0.101 0.194 0.12 0.239 c 0.139 0.285 0.177 0.315 0.216 0.315 c 0.308 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