Blood virosphere in febrile Tanzanian children.

Cordey, Samuel; Laubscher, Florian; Hartley, Mary-Anne; Junier, Thomas; Keitel, Kristina; Docquier, Mylène; Guex, Nicolas; Iseli, Christian; Vieille, Gael; Le Mercier, Philippe; Gleizes, Anne; Samaka, Josephine; Mlaganile, Tarsis; Kagoro, Frank; Masimba, John; Said, Zamzam; Temba, Hosiana; Elbanna, Gasser H; Tapparel, Caroline; Zanella, Marie-Celine; ... (2021). Blood virosphere in febrile Tanzanian children. Emerging microbes & infections, 10(1), pp. 982-993. Taylor & Francis 10.1080/22221751.2021.1925161

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Viral infections are the leading cause of childhood acute febrile illnesses motivating consultation in sub-Saharan Africa. The majority of causal viruses are never identified in low-resource clinical settings as such testing is either not part of routine screening or available diagnostic tools have limited ability to detect new/unexpected viral variants. An in-depth exploration of the blood virome is therefore necessary to clarify the potential viral origin of fever in children. Metagenomic next-generation sequencing is a powerful tool for such broad investigations, allowing the detection of RNA and DNA viral genomes. Here, we describe the blood virome of 816 febrile children (<5 years) presenting at outpatient departments in Dar es Salaam over one-year. We show that half of the patients (394/816) had at least one detected virus recognized as causes of human infection/disease (13.8% enteroviruses (enterovirus A, B, C, and rhinovirus A and C), 12% rotaviruses, 11% human herpesvirus type 6). Additionally, we report the detection of a large number of viruses (related to arthropod, vertebrate or mammalian viral species) not yet known to cause human infection/disease, highlighting those who should be on the radar, deserve specific attention in the febrile paediatric population and, more broadly, for surveillance of emerging pathogens.Trial registration: identifier: NCT02225769.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Notfallzentrum für Kinder und Jugendliche
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Keitel, Kristina


600 Technology > 610 Medicine & health




Taylor & Francis




Anette van Dorland

Date Deposited:

17 Nov 2021 07:19

Last Modified:

05 Dec 2022 15:54

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Blood virome children fever metagenomic next-generation sequencing virosphere




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