Localised increase in regional cerebral perfusion in patients with visual snow syndrome: a pseudo-continuous arterial spin labelling study.

Puledda, Francesca; Schankin, Christoph J; O'Daly, Owen; Ffytche, Dominic; Eren, Ozan; Karsan, Nazia; Williams, Steve C R; Zelaya, Fernando; Goadsby, Peter J (2021). Localised increase in regional cerebral perfusion in patients with visual snow syndrome: a pseudo-continuous arterial spin labelling study. Journal of neurology, neurosurgery, and psychiatry, 92(9), pp. 918-926. BMJ Publishing Group 10.1136/jnnp-2020-325881

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OBJECTIVES

We aimed to investigate changes in regional cerebral blood flow (rCBF) using arterial spin labelling (ASL) in patients with visual snow syndrome (VSS), in order to understand more about the underlying neurobiology of the condition, which remains mostly unknown.

METHODS

We performed an MRI study in which whole-brain maps of rCBF were obtained using pseudo-continuous ASL. Twenty-four patients with VSS and an equal number of gender and age-matched healthy volunteers took part in the study. All subjects were examined with both a visual paradigm consisting of a visual-snow like stimulus, simulating key features of the snow, and a blank screen at rest, randomly presented.

RESULTS

Patients with VSS had higher rCBF than controls over an extensive brain network, including the bilateral cuneus, precuneus, supplementary motor cortex, premotor cortex and posterior cingulate cortex, as well as the left primary auditory cortex, fusiform gyrus and cerebellum. These areas were largely analogous comparing patients either at rest, or when looking at a 'snow-like' visual stimulus. This widespread, similar pattern of perfusion differences in either condition suggests a neurophysiological signature of visual snow. Furthermore, right insula rCBF was increased in VSS subjects compared with controls during visual stimulation, reflecting a greater task-related change and suggesting a difference in interoceptive processing with constant perception of altered visual input.

CONCLUSION

The data suggest VSS patients have marked differences in brain processing of visual stimuli, validating its neurobiological basis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Schankin, Christoph Josef

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1468-330X

Publisher:

BMJ Publishing Group

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

08 Nov 2021 15:08

Last Modified:

08 Nov 2021 15:16

Publisher DOI:

10.1136/jnnp-2020-325881

PubMed ID:

34261750

BORIS DOI:

10.48350/160564

URI:

https://boris.unibe.ch/id/eprint/160564

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