Murine T-Cell Transfer Colitis as a Model for Inflammatory Bowel Disease.

Maschmeyer, Patrick; Zimmermann, Jakob; Kühl, Anja Andrea (2021). Murine T-Cell Transfer Colitis as a Model for Inflammatory Bowel Disease. Methods in molecular biology, 2285, pp. 349-373. Springer 10.1007/978-1-0716-1311-5_26

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Inflammatory bowel disease (IBD) is a group of severe chronic inflammatory conditions of the human gastrointestinal tract. Murine models of colitis have been invaluable tools to improve the understanding of IBD development and pathogenesis. While the disease etiology of IBD is complex and multifactorial, CD4+ T helper cells have been shown to strongly contribute to the disease pathogenesis of IBD. Here, we present a detailed protocol of the preclinical model of T-cell transfer colitis, which can easily be utilized in the laboratory to study T helper cell functions in intestinal inflammation.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

UniBE Contributor:

Zimmermann, Jakob

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1940-6029

Publisher:

Springer

Language:

English

Submitter:

Rahel Fuhrer

Date Deposited:

08 Nov 2021 16:25

Last Modified:

08 Nov 2021 16:25

Publisher DOI:

10.1007/978-1-0716-1311-5_26

PubMed ID:

33928564

Uncontrolled Keywords:

Adoptive transfer Chronic inflammation Colitis model Inflammatory bowel disease Intestinal inflammation Mouse model T cells T helper cells T helper lymphocytes T lymphocytes

BORIS DOI:

10.48350/160617

URI:

https://boris.unibe.ch/id/eprint/160617

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