Sleep apnea syndrome and subthalamic stimulation in Parkinson's disease.

Bargiotas, Panagiotis; Bargiotas, Ioannis; Debove, Ines; Lachenmayer, M. Lenard; Vayatis, Nicolas; Schuepbach, W. M.Michael; Bassetti, Claudio L.A. (2021). Sleep apnea syndrome and subthalamic stimulation in Parkinson's disease. Sleep medicine, 86, pp. 106-112. Elsevier 10.1016/j.sleep.2021.07.031

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Τhe association between Parkinson's disease (PD) and sleep apnea syndrome (SAS) is not fully elucidated and very few studies reported on SAS outcome after deep brain stimulation (DBS). Here, we compare the clinical profile of PD patients with and without SAS and assess, for the first time, the value of pre-DBS SAS as predictor of post-DBS outcome in PD.


Fifty patients were grouped into PD with SAS (PD-SAS+,n = 22) and without (PD-SAS-,n = 28), based on the Apnea-Hypopnea-Index (AHI≥5) in polysomnography. We used novel multivariate statistical models to compare pre-DBS profiles and assess post-DBS motor, non-motor and quality of life (QoL) changes in both groups.


In the entire cohort, 44% of patients had at least mild SAS (AHI≥5), while 22% had at least moderate (AHI≥15). Mean AHI was 11/h (NREM-AHI = 10.2/h and REM-AHI = 13.5/h). The two groups had equal demographics and PD characteristics, and did not differ in respect to unified Parkinson's disease rating scale (UPDRS)-IIOFF, Body-Mass-Index, polysomnographic features, RBD, depression, sleepiness and QoL scores. The PD-SAS+ group had significantly higher scores in UPDRS-IIIOFF (41.1 ± 17.7 vs. 30.9 ± 11.7,p < 0.05) compared to PD-SAS- group. The groups did not differ in respect to post-DBS change in UPDRS-II, UPDRS-III, Epworth sleepiness scale, Hamilton depression rating scale and PDQ39 scores. Positive airway pressure therapy had no impact on post-DBS outcome.


In patients with PD and candidates for DBS, the presence of SAS is associated with increased motor signs, but not with a specific non-motor, QoL or sleep-wake profile. The presence of SAS prior to STN-DBS is not associated with worse outcome after surgery.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Bargiotas, Panagiotis, Debove, Ines, Lachenmayer, Lenard, Schüpbach, Michael, Bassetti, Claudio L.A.


600 Technology > 610 Medicine & health








Chantal Kottler

Date Deposited:

22 Nov 2021 16:22

Last Modified:

05 Dec 2022 15:54

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Deep brain stimulation Parkinson's disease Sleep apnea Sleep-disordered breathing Sleep-wake disturbances




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