Live cell imaging techniques to study T cell trafficking across the blood-brain barrier in vitro and in vivo

Coisne, Caroline; Lyck, Ruth; Engelhardt, Britta (2013). Live cell imaging techniques to study T cell trafficking across the blood-brain barrier in vitro and in vivo. Fluids and barriers of the CNS, 10(1), p. 7. London: BioMed Central

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BACKGROUND The central nervous system (CNS) is an immunologically privileged site to which access for circulating immune cells is tightly controlled by the endothelial blood-brain barrier (BBB) located in CNS microvessels. Under physiological conditions immune cell migration across the BBB is low. However, in neuroinflammatory diseases such as multiple sclerosis, many immune cells can cross the BBB and cause neurological symptoms. Extravasation of circulating immune cells is a multi-step process that is regulated by the sequential interaction of different adhesion and signaling molecules on the immune cells and on the endothelium. The specialized barrier characteristics of the BBB, therefore, imply the existence of unique mechanisms for immune cell migration across the BBB.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Engelhardt, Britta

ISSN:

2045-8118

Publisher:

BioMed Central

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:39

Last Modified:

07 Dec 2014 00:59

PubMed ID:

23336847

BORIS DOI:

10.7892/boris.16082

URI:

https://boris.unibe.ch/id/eprint/16082 (FactScience: 223645)

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