Characterization of Hyperacute Neuropathic Pain after Spinal Cord Injury: A Prospective Study.

Rosner, Jan; Negraeff, Michael; Bélanger, Lise M; Tsang, Angela; Ritchie, Leanna; Mac-Thiong, Jean-Marc; Christie, Sean; Wilson, Jefferson R; Dhall, Sanjay; Charest-Morin, Raphaële; Street, John; Ailon, Tamir; Paquette, Scott; Dea, Nicolas; Fisher, Charles G; Dvorak, Marcel F; Finnerup, Nanna B; Kwon, Brian K; Kramer, John L K (2022). Characterization of Hyperacute Neuropathic Pain after Spinal Cord Injury: A Prospective Study. The journal of pain, 23(1), pp. 89-97. Elsevier 10.1016/j.jpain.2021.06.013

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There is currently a lack of information regarding neuropathic pain in the very early stages of spinal cord injury (SCI). In the present study, neuropathic pain was assessed using the Douleur Neuropathique 4 Questions (DN4) for the patient's worst pain within the first 5 days of injury (i.e., hyperacute) and on follow-up at 3, 6, and 12 months. Within the hyperacute time frame (i.e., 5 days), at- and below-level neuropathic pain were reported as the worst pain in 23% (n = 18) and 5% (n = 4) of individuals with SCI, respectively. Compared to the neuropathic pain observed in this hyperacute setting, late presenting neuropathic pain was characterized by more intense painful electrical and cold sensations, but less itching sensations. Phenotypic differences between acute and late neuropathic pain support the incorporation of timing into a mechanism-based classification of neuropathic pain after SCI. The diagnosis of acute neuropathic pain after SCI is challenged by the presence of nociceptive and neuropathic pains, with the former potentially masking the latter. This may lead to an underestimation of the incidence of neuropathic pain during the very early, hyperacute time points post-injury. TRIAL REGISTRATION: ClinicalTrials.gov (Identifier: NCT01279811) PERSPECTIVE: This article presents distinct pain phenotypes of hyperacute and late presenting neuropathic pain after spinal cord injury and highlights the challenges of pain assessments in the acute phase after injury. This information may be relevant to clinical trial design and broaden our understanding of neuropathic pain mechanisms after spinal cord injury.

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