Özdemir, Berna C. (2021). Androgen Signaling in the Tumor Microenvironment. In: Tumor Microenvironment, Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology: Vol. 1270 (pp. 169-183). Springer 10.1007/978-3-030-47189-7_10
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The key function of mesenchymal/stromal androgen receptor (AR) signaling for prostate development has been well documented by tissue recombination experiments. Some studies have addressed the expression and function of AR in stromal cells in prostate cancer, yet our understanding of the role of stromal AR in other tissues beyond prostate is still insufficient.Genomic analysis has revealed that cellular responses to androgens differ between epithelial and stromal cells. AR in stromal cells seems not to act via classical AR transcription factors such as FOXA1 but rather depends on the JUN/AP1 complex. Stromal AR appears to have tumor-promoting and tumor-protective functions depending on tumor stage. Loss of AR signaling in fibroblasts has been detected already in premalignant lesions in the skin and prostate and has been associated with tumor induction in xenografts of skin cancer and aggressive disease features and poor patient prognosis in prostate cancer. Moreover, AR expression is found on virtually all tissue-infiltrating immune cells and plays critical roles in immune cell function. These findings suggest a potential deleterious impact of current androgen deprivation therapies which inhibit both epithelial and stromal AR, highlighting the need to develop tissue-specific AR inhibitors.
Item Type: |
Book Section (Book Chapter) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Özdemir, Berna |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0065-2598 |
ISBN: |
978-3-030-47189-7 |
Series: |
Advances in Experimental Medicine and Biology |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Rebeka Gerber |
Date Deposited: |
24 Nov 2021 09:32 |
Last Modified: |
05 Dec 2022 15:54 |
Publisher DOI: |
10.1007/978-3-030-47189-7_10 |
PubMed ID: |
33123999 |
Uncontrolled Keywords: |
AR Androgen Androgen receptor CAFs Cancer-associated fibroblasts Dendritic cells Endothelial cells Immunity MDSC Macrophages Prostate cancer Prostate development Stroma Stromal AR Tumor microenvironment |
BORIS DOI: |
10.48350/160867 |
URI: |
https://boris.unibe.ch/id/eprint/160867 |
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