Multiple-breath washout measurements can be significantly shortened in children

Yammine, Sophie; Singer, Florian; Abbas, Chiara; Roos, Markus; Latzin, Philipp (2013). Multiple-breath washout measurements can be significantly shortened in children. Thorax, 68(6), pp. 586-7. London: BMJ Publishing Group 10.1136/thoraxjnl-2012-202345

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Multiple-breath washout (MBW)-derived lung clearance index (LCI) is a sensitive measure of ventilation inhomogeneity in patients with cystic fibrosis (CF), but LCI measurement is time consuming. We systematically assessed ways to shorten LCI measurements. In 68 school-aged children (44 with mild CF lung disease) three standard nitrogen (N2) MBWs were applied. We assessed repeatability and diagnostic performance of (1) LCI measured earlier from three MBW runs and (2) LCI measured at complete MBW (1/40th of starting N2 concentration) from two runs only. Compared with the standard LCI from three complete MBW runs, the new LCI based on three N2MBW runs until 1/20th, or two complete runs until 1/40th, provided similar or better repeatability as well as sensitivity and specificity for CF lung disease. Alternative ways to measure LCI reduced test duration in children with CF by 30% and 41%, respectively. LCI measurements can be reliably shortened in children. These new MBW protocols may advance the transition of LCI from research into clinical settings.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Yammine, Sophie; Singer, Florian; Abbas, Chiara Carolina and Latzin, Philipp

ISSN:

0040-6376

Publisher:

BMJ Publishing Group

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:40

Last Modified:

06 Dec 2013 13:38

Publisher DOI:

10.1136/thoraxjnl-2012-202345

PubMed ID:

23117979

Web of Science ID:

000318766000017

URI:

https://boris.unibe.ch/id/eprint/16095 (FactScience: 223670)

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