Vallejo-Yagüe, Enriqueta; Burkard, Theresa; Möller, Burkhard; Finckh, Axel; Burden, Andrea M (2021). Comparison of Psoriatic Arthritis and Rheumatoid Arthritis Patients across Body Mass Index Categories in Switzerland. Journal of clinical medicine, 10(14) MDPI 10.3390/jcm10143194
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Abnormal body mass index (BMI) was associated with worse rheumatic markers in psoriatic arthritis (PsA) and rheumatoid arthritis (RA). Aiming to describe PsA and RA patients stratified by BMI, we performed a descriptive study in PsA and RA patients (two distinct cohorts) in the Swiss Clinical Quality Management in Rheumatic Diseases (SCQM) registry. New users of biologic or targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) were stratified by BMI at the start of their treatment (underweight, normal weight, overweight, obese). The PsA underweight and normal weight categories were merged. Age at disease onset and further characteristics at the start of the first b/tsDMARD treatment were compared across BMI categories vs. the corresponding normal weight group. The study included 819 PsA (36.5% overweight, 23.8% obese) and 3217 RA patients (4.4% underweight, 31.8% overweight, 17.0% obese). Compared to the corresponding normal weight group, PsA and RA obese patients had significantly (p < 0.05) higher C-reactive protein, worse disease activity, and lower quality of life (QoL). Obese PsA patients had significantly worse skin manifestation and pain, while obese RA patients had significantly higher erythrocyte sedimentation rate and tender joint counts, as well as lower seropositive prevalence. To conclude, obese PsA and RA patients presented worse disease activity and poorer QoL than those with normal weight.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology and Immunology |
UniBE Contributor: |
Möller, Burkhard |
Subjects: |
600 Technology > 610 Medicine & health 600 Technology > 610 Medicine & health > 615 Pharmacology & therapeutics, prescription drugs |
ISSN: |
2077-0383 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Burkhard Möller |
Date Deposited: |
03 Dec 2021 17:54 |
Last Modified: |
05 Dec 2022 15:54 |
Publisher DOI: |
10.3390/jcm10143194 |
PubMed ID: |
34300360 |
Uncontrolled Keywords: |
biologics patient-reported outcomes psoriatic arthritis rheumatoid arthritis |
BORIS DOI: |
10.48350/161242 |
URI: |
https://boris.unibe.ch/id/eprint/161242 |
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