Pappas, Alexa; Kubsad, Sanjay; Baud, Maxime O; Wright, Kyla E; Kollmyer, Devon M; Warner, Nicole M; Haltiner, Alan M; Gwinn, Ryder P; Doherty, Michael J (2021). Does glucose influence multidien cycles of interictal and/or ictal activities? Seizure - European journal of epilepsy, 85, pp. 145-150. Elsevier 10.1016/j.seizure.2020.12.002
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PURPOSE
There are multidien patterns of seizure occurrence. Predicting seizure risk may be easier with biomarker correlates to multidien patterns. We hypothesize multiday hyper or hypoglycemia contributes to seizure risk.
METHODS
In a type I diabetic (T1D) with focal onset epilepsy with continuous glucose monitoring (CGM) and responsive neurostimulation (RNS) devices, we studied multiday interictal activities (IEA), seizures, and glucose. Hourly CGM data was matched to hourly RNS captures of interictal and ictal activities over 33 months. RNS detection settings were unchanged. Multidien cycles were analyzed, active blocks of IEA and ictal episodes defined, and tissue glucose averages studied.
RESULTS
Average glucose was 161 mg/dl. A 40-day cycle of interictal and ictal activities occurred, though no similar glucose cycle was evident. Glucose elevations relative to patient average were associated with increases in IEA but not seizure. Frequent seizures were not associated with obvious elevations or decreases of glucose from baseline, most seizures occurred at +/- 10 mg/dl of average daily glucose (i.e. 150-170 mg/dl).
CONCLUSION
Tissue glucose may influence IEA but may not influence multiday seizure activity or very frequent seizures. In an ambulatory T1D patient multiday hypo or hyperglycemic extremes do not appear to provoke seizure activities.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Baud, Maxime |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1059-1311 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Chantal Kottler |
Date Deposited: |
03 Dec 2021 10:20 |
Last Modified: |
05 Dec 2022 15:54 |
Publisher DOI: |
10.1016/j.seizure.2020.12.002 |
PubMed ID: |
33465639 |
Uncontrolled Keywords: |
Biomarker Interictal Multidien, circadian Prediction Stimulation |
BORIS DOI: |
10.48350/161320 |
URI: |
https://boris.unibe.ch/id/eprint/161320 |
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