Tissue-Resident T Cells in Chronic Relapsing-Remitting Intestinal Disorders.

Barreto de Albuquerque, Juliana; Mueller, Christoph; Gungor, Bilgi (2021). Tissue-Resident T Cells in Chronic Relapsing-Remitting Intestinal Disorders. Cells, 10(8) MDPI 10.3390/cells10081882

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Tissue-resident memory T (TRM) cells critically contribute to the rapid immunoprotection and efficient immunosurveillance against pathogens, particularly in barrier tissues, but also during anti-tumor responses. However, the involvement of TRM cells also in the induction and exacerbation of immunopathologies, notably in chronically relapsing auto-inflammatory disorders, is becoming increasingly recognized as a critical factor. Thus, TRM cells may also represent an attractive target in the management of chronic (auto-) inflammatory disorders, including multiple sclerosis, rheumatoid arthritis, celiac disease and inflammatory bowel diseases. In this review, we focus on current concepts of TRM cell biology, particularly in the intestine, and discuss recent findings on their involvement in chronic relapsing-remitting inflammatory disorders. Potential therapeutic strategies to interfere with these TRM cell-mediated immunopathologies are discussed.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology

UniBE Contributor:

Barreto de Albuquerque, Juliana; Müller, Christoph and Gungor, Bilgi

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2073-4409

Publisher:

MDPI

Language:

English

Submitter:

Christa Hagert

Date Deposited:

18 Nov 2021 15:05

Last Modified:

18 Nov 2021 15:13

Publisher DOI:

10.3390/cells10081882

PubMed ID:

34440651

Uncontrolled Keywords:

T cell retention circulating T cells intestinal inflammation memory T cells tissue-resident T cells

BORIS DOI:

10.48350/161345

URI:

https://boris.unibe.ch/id/eprint/161345

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