Achard, V.; Putora, P. M.; Omlin, A.; Zilli, T.; Fischer, S. (2022). Metastatic Prostate Cancer: Treatment Options. Oncology, 100(1), pp. 48-59. Karger 10.1159/000519861
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BACKGROUND
Metastatic prostate cancer (PCa) is associated with considerable diminished overall survival (OS). Standard treatment for metastatic PCa has long been androgen deprivation therapy alone, with patients initially responding to this treatment and then progressing to a castration-resistant phase.
SUMMARY
The advent of novel therapeutic agents has changed this paradigm, with high-level evidence that upfront combination therapy with either docetaxel or new hormonal agents results in improved OS for patients with metastatic hormone-sensitive PCa. In the absence of a comprehensive clinical trial investigating the comparative efficacy and safety of all agents, clinicians are responsible for choosing the most appropriate therapy in close coordination with patients. Furthermore, the same therapeutic agents are also efficient in the castration-resistant phase, leading to the issue of the best therapeutic sequence. Finally, along with systemic therapy and molecular imaging advancements, radiotherapy was investigated in the oligometastatic setting, whether it is to treat the primary tumour or metastases. Key Messages: In this complex landscape, where providers have multiple effective therapeutic options to treat metastatic PCa patients, priority must be given to determine which treatment combination and sequence is best suited to a particular patient, given his comorbidities and preferences.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology |
UniBE Contributor: |
Putora, Paul Martin |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1423-0232 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Beatrice Scheidegger |
Date Deposited: |
07 Dec 2021 12:18 |
Last Modified: |
20 Sep 2023 13:09 |
Publisher DOI: |
10.1159/000519861 |
PubMed ID: |
34781285 |
Uncontrolled Keywords: |
Androgen deprivation Castration-resistant prostate cancer Metastatic hormone-sensitive prostate cancer New hormonal agents Quality of life Radiopharmaceuticals Radiotherapy |
BORIS DOI: |
10.48350/161418 |
URI: |
https://boris.unibe.ch/id/eprint/161418 |
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