Liabeuf, Sophie; Pepin, Marion; Franssen, Casper F M; Viggiano, Davide; Carriazo, Sol; Gansevoort, Ron T; Gesualdo, Loreto; Hafez, Gaye; Malyszko, Jolanta; Mayer, Christopher; Nitsch, Dorothea; Ortiz, Alberto; Pešić, Vesna; Wiecek, Andrzej; Massy, Ziad A (2021). Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle? Nephrology, dialysis, transplantation, 37(Supplement_2), ii33-ii44. Oxford University Press 10.1093/ndt/gfab223
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Chronic kidney disease (CKD) perturbs the crosstalk with others organs, with the interaction between the kidneys and the heart having been studied most intensively. However, a growing body of data indicates that there is an association between kidney dysfunction and disorders of the central nervous system. In epidemiological studies, CKD is associated with a high prevalence of neurological complications, such as cerebrovascular disorders, movement disorders, cognitive impairment and depression. Along with traditional cardiovascular risk factors (such as diabetes, inflammation, hypertension and dyslipidaemia), non-traditional risk factors related to kidney damage (such as uraemic toxins) may predispose patients with CKD to neurological disorders. There is increasing evidence to show that uraemic toxins, for example indoxyl sulphate, have a neurotoxic effect. A better understanding of factors responsible for the elevated prevalence of neurological disorders among patients with CKD might facilitate the development of novel treatments. Here, we review (i) the potential clinical impact of CKD on cerebrovascular and neurological complications, (ii) the mechanisms underlying the uraemic toxins' putative action (based on pre-clinical and clinical research) and (iii) the potential impact of these findings on patient care.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension |
ISSN: |
0931-0509 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Laila-Yasmin Mani |
Date Deposited: |
15 Dec 2021 15:05 |
Last Modified: |
30 Dec 2021 00:13 |
Publisher DOI: |
10.1093/ndt/gfab223 |
PubMed ID: |
34718753 |
Additional Information: |
CONNECT Action (Cognitive Decline in Nephro-Neurology European Cooperative Target): Laila-Yasmin Mani |
Uncontrolled Keywords: |
CKD cardiovascular indoxyl sulphate stroke uraemic toxins |
BORIS DOI: |
10.48350/161519 |
URI: |
https://boris.unibe.ch/id/eprint/161519 |
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