Interactions between the microbiota and the immune system

Hooper, Lora V; Littman, Dan R; Macpherson, Andrew J (2012). Interactions between the microbiota and the immune system. Science, 336(6086), pp. 1268-73. Washington, D.C.: American Association for the Advancement of Science 10.1126/science.1223490

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The large numbers of microorganisms that inhabit mammalian body surfaces have a highly coevolved relationship with the immune system. Although many of these microbes carry out functions that are critical for host physiology, they nevertheless pose the threat of breach with ensuing pathologies. The mammalian immune system plays an essential role in maintaining homeostasis with resident microbial communities, thus ensuring that the mutualistic nature of the host-microbial relationship is maintained. At the same time, resident bacteria profoundly shape mammalian immunity. Here, we review advances in our understanding of the interactions between resident microbes and the immune system and the implications of these findings for human health.

Item Type:

Journal Article (Further Contribution)


04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology

UniBE Contributor:

Macpherson, Andrew




American Association for the Advancement of Science




Factscience Import

Date Deposited:

04 Oct 2013 14:40

Last Modified:

06 Dec 2013 13:38

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URI: (FactScience: 223740)

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