Dysbalance in sympathetic neurotransmitter release and action in cirrhotic rats: impact of exogenous neuropeptide Y

Dietrich, P; Moleda, L; Kees, F; Müller, M; Straub, R H; Hellerbrand, C; Wiest, R (2013). Dysbalance in sympathetic neurotransmitter release and action in cirrhotic rats: impact of exogenous neuropeptide Y. Journal of hepatology, 58(2), pp. 254-61. Amsterdam: Elsevier 10.1016/j.jhep.2012.09.027

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Splanchnic vasodilation is an essential disturbance in portal hypertension. Increased systemic sympathetic nerve activity is well known, but potential corresponding vascular desensitization is incompletely characterized. Release of splanchnic sympathetic neurotransmitters noradrenaline (NA) and co-transmitter neuropeptide Y (NPY) remains to be elucidated. Finally, the effects of exogenous NPY on these mechanisms are unexplored.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology

UniBE Contributor:

Wiest, Reiner

ISSN:

0168-8278

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:40

Last Modified:

06 Dec 2013 13:38

Publisher DOI:

10.1016/j.jhep.2012.09.027

PubMed ID:

23041305

Web of Science ID:

000315069900010

URI:

https://boris.unibe.ch/id/eprint/16161 (FactScience: 223749)

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