Cell-based therapy for myocardial repair in patients with acute myocardial infarction: rationale and study design of the SWiss multicenter Intracoronary Stem cells Study in Acute Myocardial Infarction (SWISS-AMI)

Sürder, Daniel; Schwitter, Jürg; Moccetti, Tiziano; Astori, Giuseppe; Rufibach, Kaspar; Plein, Sven; Lo Cicero, Viviana; Soncin, Sabrina; Windecker, Stephan; Moschovitis, Aris; Wahl, Andreas; Erne, Paul; Jamshidi, Peiman; Auf der Maur, Christoph; Manka, Robert; Soldati, Gianni; Bühler, Ines; Wyss, Christophe; Landmesser, Ulf; Lüscher, Thomas F; ... (2010). Cell-based therapy for myocardial repair in patients with acute myocardial infarction: rationale and study design of the SWiss multicenter Intracoronary Stem cells Study in Acute Myocardial Infarction (SWISS-AMI). American Heart Journal, 160(1), pp. 58-64. St. Louis, Mo.: Elsevier 10.1016/j.ahj.2010.03.039

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Recent studies report that intracoronary administration of autologous bone marrow mononucleated cells (BM-MNCs) may improve remodeling of the left ventricle after acute myocardial infarction (AMI). Subgroup analysis suggest that early treatment between days 4 and 7 after AMI is probably most effective; however, the optimal time point of intracoronary cell administration has never been addressed in clinical trials. Furthermore, reliable clinical predictors are lacking for identifying patients who are thought to have most benefit from cellular therapy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Windecker, Stephan; Moschovitis, Aris and Wahl, Andreas

ISSN:

0002-8703

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:10

Last Modified:

06 Mar 2014 23:03

Publisher DOI:

10.1016/j.ahj.2010.03.039

PubMed ID:

20598973

Web of Science ID:

000279440400010

URI:

https://boris.unibe.ch/id/eprint/1617 (FactScience: 203395)

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