Reversible severe glycogenic hepatopathy in type 1 diabetes.

de Laffolie, Jan; Kamrath, Clemens; Burchert, Diana; Böttcher, Claudia; Wudy, Stefan Alexander; Zimmer, Klaus-Peter (2022). Reversible severe glycogenic hepatopathy in type 1 diabetes. Wiener medizinische Wochenschrift, 172(5-6), pp. 144-147. Springer 10.1007/s10354-020-00795-6

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CASE PRESENTATION

We report a case of severe glycogenic hepatopathy in a 17-year-old boy with poorly controlled type 1 diabetes. On presentation, major findings included unexplained pronounced hepatomegaly and increased liver enzymes, ferritin, and triglycerides. Histology and electron microscopy evaluation showed severe glycogen storage, steatosis, and signs of fibrosis, resembling the histomorphological findings of Mauriac syndrome. After information about the nature of the disease and intensification of insulin therapy with insulin pump, liver enzymes, ferritin, and triglycerides normalized within 1 month.

CONCLUSION

Glycogenic hepatopathy is a rare but important potential complication in poorly controlled juvenile diabetic patients. With improved metabolic control, it is fully reversible.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Endocrinology/Metabolic Disorders

UniBE Contributor:

Böttcher, Claudia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0043-5341

Publisher:

Springer

Language:

English

Submitter:

Anette van Dorland

Date Deposited:

07 Dec 2021 18:24

Last Modified:

05 Dec 2022 15:55

Publisher DOI:

10.1007/s10354-020-00795-6

PubMed ID:

33471221

Uncontrolled Keywords:

Diabetes Glycogen Hepatopathy Metabolic control Pediatric hepatology

BORIS DOI:

10.48350/161757

URI:

https://boris.unibe.ch/id/eprint/161757

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