A 3D deep learning model to predict the diagnosis of dementia with Lewy bodies, Alzheimer's disease, and mild cognitive impairment using brain 18F-FDG PET.

Etminani, Kobra; Soliman, Amira; Davidsson, Anette; Chang, Jose R; Martínez-Sanchis, Begoña; Byttner, Stefan; Camacho, Valle; Bauckneht, Matteo; Stegeran, Roxana; Ressner, Marcus; Agudelo-Cifuentes, Marc; Chincarini, Andrea; Brendel, Matthias; Rominger, Axel; Bruffaerts, Rose; Vandenberghe, Rik; Kramberger, Milica G; Trost, Maja; Nicastro, Nicolas; Frisoni, Giovanni B; ... (2022). A 3D deep learning model to predict the diagnosis of dementia with Lewy bodies, Alzheimer's disease, and mild cognitive impairment using brain 18F-FDG PET. European journal of nuclear medicine and molecular imaging, 49(2), pp. 563-584. Springer 10.1007/s00259-021-05483-0

Etminani2021_Article_A3DDeepLearningModelToPredictT.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (3MB) | Preview


The purpose of this study is to develop and validate a 3D deep learning model that predicts the final clinical diagnosis of Alzheimer's disease (AD), dementia with Lewy bodies (DLB), mild cognitive impairment due to Alzheimer's disease (MCI-AD), and cognitively normal (CN) using fluorine 18 fluorodeoxyglucose PET (18F-FDG PET) and compare model's performance to that of multiple expert nuclear medicine physicians' readers.


Retrospective 18F-FDG PET scans for AD, MCI-AD, and CN were collected from Alzheimer's disease neuroimaging initiative (556 patients from 2005 to 2020), and CN and DLB cases were from European DLB Consortium (201 patients from 2005 to 2018). The introduced 3D convolutional neural network was trained using 90% of the data and externally tested using 10% as well as comparison to human readers on the same independent test set. The model's performance was analyzed with sensitivity, specificity, precision, F1 score, receiver operating characteristic (ROC). The regional metabolic changes driving classification were visualized using uniform manifold approximation and projection (UMAP) and network attention.


The proposed model achieved area under the ROC curve of 96.2% (95% confidence interval: 90.6-100) on predicting the final diagnosis of DLB in the independent test set, 96.4% (92.7-100) in AD, 71.4% (51.6-91.2) in MCI-AD, and 94.7% (90-99.5) in CN, which in ROC space outperformed human readers performance. The network attention depicted the posterior cingulate cortex is important for each neurodegenerative disease, and the UMAP visualization of the extracted features by the proposed model demonstrates the reality of development of the given disorders.


Using only 18F-FDG PET of the brain, a 3D deep learning model could predict the final diagnosis of the most common neurodegenerative disorders which achieved a competitive performance compared to the human readers as well as their consensus.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Rominger, Axel Oliver


600 Technology > 610 Medicine & health








Daria Vogelsang

Date Deposited:

07 Jan 2022 11:19

Last Modified:

02 Feb 2022 00:13

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Alzheimer’s disease Artificial intelligence Deep learning Dementia with Lewy bodies FDG PET Mild cognitive impairment





Actions (login required)

Edit item Edit item
Provide Feedback